Thornley T, Marshall G, Howard P, Wilson A P R
Boots UK, Nottingham NG90 1BS, UK.
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
J Antimicrob Chemother. 2016 Nov;71(11):3293-3299. doi: 10.1093/jac/dkw264. Epub 2016 Jul 20.
The UK 5 year antimicrobial resistance strategy recognizes the role of point-of-care diagnostics to identify where antimicrobials are required, as well as to assess the appropriateness of the diagnosis and treatment. A sore throat test-and-treat service was introduced in 35 community pharmacies across two localities in England during 2014-15.
Trained pharmacy staff assessed patients presenting with a sore throat using the Centor scoring system and patients meeting three or all four of the criteria were offered a throat swab test for Streptococcus pyogenes, Lancefield group A streptococci. Patients with a positive throat swab test were offered antibiotic treatment.
Following screening by pharmacy staff, 149/367 (40.6%) patients were eligible for throat swab testing. Of these, only 36/149 (24.2%) were positive for group A streptococci. Antibiotics were supplied to 9.8% (n = 36/367) of all patients accessing the service. Just under half of patients that were not showing signs of a bacterial infection (60/123, 48.8%) would have gone to their general practitioner if the service had not been available.
This study has shown that it is feasible to deliver a community-pharmacy-based screening and treatment service using point-of-care testing. This type of service has the potential to support the antimicrobial resistance agenda by reducing unnecessary antibiotic use and inappropriate antibiotic consumption.
英国5年抗菌药物耐药性战略认识到即时诊断在确定何处需要抗菌药物以及评估诊断和治疗的适当性方面的作用。2014 - 15年期间,在英格兰两个地区的35家社区药房引入了咽喉痛检测与治疗服务。
经过培训的药房工作人员使用森托评分系统对出现咽喉痛的患者进行评估,符合三项或全部四项标准的患者接受A群化脓性链球菌咽喉拭子检测。咽喉拭子检测呈阳性的患者接受抗生素治疗。
经过药房工作人员筛查,149/367(40.6%)名患者符合咽喉拭子检测条件。其中,只有36/149(24.2%)的患者A群链球菌检测呈阳性。在所有使用该服务的患者中,9.8%(n = 36/367)的患者获得了抗生素。如果没有这项服务,近一半没有细菌感染迹象的患者(60/123,48.8%)会去看全科医生。
本研究表明,利用即时检测提供基于社区药房的筛查和治疗服务是可行的。这类服务有潜力通过减少不必要的抗生素使用和不适当的抗生素消费来支持抗菌药物耐药性议程。