立体定向体部放射治疗局限性前列腺癌

Stereotactic Body Radiation Therapy for Localized Prostate Cancer.

作者信息

Lischalk Jonathan W, Kaplan Irving D, Collins Sean P

机构信息

From the *Department of Radiation Medicine, Georgetown University Hospital, Washington, DC; and †Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Finard Basement, Boston, MA.

出版信息

Cancer J. 2016 Jul-Aug;22(4):307-13. doi: 10.1097/PPO.0000000000000209.

Abstract

Stereotactic body radiation therapy (SBRT) has become a viable treatment option for the many patients who receive a diagnosis of localized prostate cancer each year. Technological advancements have led to tight target conformality, allowing for high-dose-per-fraction delivery without untoward normal tissue toxicity. Biochemical control, now reported up to 5 years, appears to compare favorably with dose-escalated conventionally fractionated radiotherapy. Moreover, toxicity and quality of life follow-up data indicate genitourinary and gastrointestinal toxicities are likewise comparable to conventional radiation therapy. Nevertheless, because of the long natural history of prostate cancer, extended follow-up will be necessary to confirm these impressive initial results. Within this prostate SBRT review, we explore the detailed rationale for SBRT treatment, the diverse SBRT techniques utilized and their unique technical considerations, and finally data for SBRT clinical efficacy and treatment-related toxicity.

摘要

立体定向体部放射治疗(SBRT)已成为每年众多被诊断为局限性前列腺癌患者的一种可行治疗选择。技术进步带来了精确的靶区适形性,使得能够进行高剂量分次照射,而不会对正常组织产生不良毒性。目前报告的长达5年的生化控制情况似乎与剂量递增的传统分割放疗效果相当。此外,毒性和生活质量随访数据表明,泌尿生殖系统和胃肠道毒性同样与传统放疗相当。然而,由于前列腺癌的自然病程较长,需要进行长期随访以证实这些令人印象深刻的初步结果。在本次前列腺SBRT综述中,我们探讨了SBRT治疗的详细原理、所采用的各种SBRT技术及其独特的技术考量,最后还探讨了SBRT临床疗效和治疗相关毒性的数据。

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