Dols Annemiek, Kessing Lars Vedel, Strejilevich Sergio A, Rej Soham, Tsai Shang-Ying, Gildengers Ariel G, Almeida Osvaldo P, Shulman Kenneth I, Sajatovic Martha
Old Age Psychiatry, GGZinGeest, VU Medical Center, Amsterdam, The Netherlands.
Psychiatric Center Copenhagen, Faculty of Health and Medical Sciences, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Int J Geriatr Psychiatry. 2016 Dec;31(12):1295-1300. doi: 10.1002/gps.4534. Epub 2016 Jul 21.
Older adults with bipolar disorder (OABD) are a growing segment of patients with bipolar disorder (BD) for which specific guidelines are warranted. Although, OABD are frequently excluded from randomized controlled trials due to their age or somatic comorbidity, more treatment data from a variety of sources have become available in recent years. It is expected that at least some of this emerging information on OABD would be incorporated into treatment guidelines available to clinicians around the world.
The International Society of Bipolar Disorders OABD task force compiled and compared recommendations from current national and international guidelines that specifically address geriatric or older individuals with BD (from year 2005 onwards).
There were 34 guidelines, representing six continents and 19 countries. The majority of guidelines had no separate section on OABD. General principles for treating OABD with medication are recommended to be similar to those for younger adults, with special caution for side effects due to somatic comorbidity and concomitant medications. Therapeutic lithium serum levels are suggested to be lower but recommendations are very general and mostly not informed by specific research evidence.
There is a lack of emphasis of OABD-specific issues in existing guidelines. Given the substantial clinical heterogeneity in BD across the life span, along with the rapidly expanding population of older individuals worldwide, and limited mental health workforce with geriatric expertise, it is critical that additional effort and resources be devoted to studying treatment interventions specific to OABD and that treatment guidelines reflect research findings. Copyright © 2016 John Wiley & Sons, Ltd.
老年双相情感障碍患者(OABD)在双相情感障碍(BD)患者中所占比例日益增加,因此需要制定专门的指南。尽管OABD患者常因年龄或躯体合并症被排除在随机对照试验之外,但近年来已从各种来源获得了更多治疗数据。预计关于OABD的至少一些新信息将被纳入世界各地临床医生可用的治疗指南中。
国际双相情感障碍协会OABD特别工作组汇编并比较了当前国家和国际指南(自2005年起)中针对老年或年长BD患者的建议。
有34份指南,代表六大洲和19个国家。大多数指南没有关于OABD的单独章节。建议使用药物治疗OABD的一般原则与治疗年轻成年人的原则相似,但要特别注意躯体合并症和同时使用的药物所引起的副作用。建议治疗性锂血清水平较低,但建议非常笼统,且大多没有具体研究证据支持。
现有指南缺乏对OABD特定问题的强调。鉴于双相情感障碍在整个生命周期中存在显著的临床异质性,以及全球老年人口迅速增加,而具有老年医学专业知识的精神卫生工作人员有限,因此必须投入更多的努力和资源来研究针对OABD的治疗干预措施,并且治疗指南应反映研究结果。版权所有© 2016约翰威立国际出版公司。