Singla Navneet, Kapoor Ankur, Chatterjee Debajyoti, Radotra B D
Department of Neurosurgery, PGIMER Chandigarh, Chandigarh, 160012, India.
Department of Histopathology, PGIMER Chandigarh, Panchkula, India.
Childs Nerv Syst. 2016 Dec;32(12):2471-2474. doi: 10.1007/s00381-016-3178-z. Epub 2016 Jul 21.
Malignant rhabdoid tumor (MRT) is an aggressive tumor of infancy and childhood that rarely presents as a primary spinal or spinal cord tumor. There are only three reported cases of spinal MRT in infants.
We present a similar case in a 3-month male child who developed ultra-early recurrence, 4 weeks after complete excision. The diagnosis was confirmed by immunohistochemistry showing inactivation of the INI1 gene.
Despite surgical excision and adjuvant chemoradiotherapy, these tumors have a progressive course and recurrence is a common phenomenon.
We believe that MRT must be considered in the differential diagnosis of the intra/paraspinal masses, especially in the infants.
恶性横纹肌样瘤（MRT）是一种婴幼儿期侵袭性肿瘤，很少表现为原发性脊柱或脊髓肿瘤。婴儿脊柱MRT仅有3例报道。
我们报告了一名3个月大男童的类似病例，该患儿在完全切除术后4周出现超早期复发。免疫组化显示INI1基因失活，确诊为此病。
尽管进行了手术切除和辅助放化疗，这些肿瘤仍呈进展性病程，复发很常见。
我们认为，在鉴别诊断椎内/椎旁肿块时，尤其是婴儿，必须考虑MRT。
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