Zhang Kaile, Zhou Shukui, Wang Leilei, Wang Jianlong, Zou Qingsong, Zhao Weixin, Fu Qiang, Fang Xiaolan
The Department of Urology, Affiliated Sixth People's Hospital, Shanghai JiaoTong University, Shanghai 200233, China.
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA.
Int J Mol Sci. 2016 Jul 19;17(7):1163. doi: 10.3390/ijms17071163.
Currently there is little effective treatment available for castration resistant prostate cancer, which is responsible for the majority of prostate cancer related deaths. Emerging evidence suggested that cancer stem cells might play an important role in resistance to traditional cancer therapies, and the studies of cancer stem cells (including specific isolation and targeting on those cells) might benefit the discovery of novel treatment of prostate cancer, especially castration resistant disease. In this review, we summarized major biomarkers for prostate cancer stem cells, as well as their functional mechanisms and potential application in clinical diagnosis and treatment of patients.
目前，对于去势抵抗性前列腺癌几乎没有有效的治疗方法，而这种癌症导致了大多数与前列腺癌相关的死亡。新出现的证据表明，癌症干细胞可能在对传统癌症治疗的抵抗中发挥重要作用，对癌症干细胞的研究（包括对这些细胞的特异性分离和靶向）可能有助于发现前列腺癌的新治疗方法，尤其是去势抵抗性疾病的治疗方法。在这篇综述中，我们总结了前列腺癌干细胞的主要生物标志物，以及它们的功能机制和在患者临床诊断与治疗中的潜在应用。
