Miller Robert, Stalder Tobias, Jarczok Marc, Almeida David M, Badrick Ellena, Bartels Meike, Boomsma Dorret I, Coe Christopher L, Dekker Marieke C J, Donzella Bonny, Fischer Joachim E, Gunnar Megan R, Kumari Meena, Lederbogen Florian, Power Christine, Ryff Carol D, Subramanian S V, Tiemeier Henning, Watamura Sarah E, Kirschbaum Clemens
Institute of General Psychology, Biopsychology and Psychological Methods, Technische Universität Dresden, Zellescher Weg 19, D-01069 Dresden, Germany.
Institute of General Psychology, Biopsychology and Psychological Methods, Technische Universität Dresden, Zellescher Weg 19, D-01069 Dresden, Germany.
Psychoneuroendocrinology. 2016 Nov;73:16-23. doi: 10.1016/j.psyneuen.2016.07.201. Epub 2016 Jul 14.
Diurnal salivary cortisol profiles are valuable indicators of adrenocortical functioning in epidemiological research and clinical practice. However, normative reference values derived from a large number of participants and across a wide age range are still missing. To fill this gap, data were compiled from 15 independently conducted field studies with a total of 104,623 salivary cortisol samples obtained from 18,698 unselected individuals (mean age: 48.3 years, age range: 0.5-98.5 years, 39% females). Besides providing a descriptive analysis of the complete dataset, we also performed mixed-effects growth curve modeling of diurnal salivary cortisol (i.e., 1-16h after awakening). Cortisol decreased significantly across the day and was influenced by both, age and sex. Intriguingly, we also found a pronounced impact of sampling season with elevated diurnal cortisol in spring and decreased levels in autumn. However, the majority of variance was accounted for by between-participant and between-study variance components. Based on these analyses, reference ranges (LC/MS-MS calibrated) for cortisol concentrations in saliva were derived for different times across the day, with more specific reference ranges generated for males and females in different age categories. This integrative summary provides important reference values on salivary cortisol to aid basic scientists and clinicians in interpreting deviations from the normal diurnal cycle.
在流行病学研究和临床实践中,昼夜唾液皮质醇水平是肾上腺皮质功能的重要指标。然而,目前仍缺乏来自大量参与者且涵盖广泛年龄范围的标准参考值。为填补这一空白,我们汇总了15项独立开展的实地研究的数据,这些研究共采集了18,698名未经筛选个体(平均年龄:48.3岁,年龄范围:0.5 - 98.5岁,女性占39%)的104,623份唾液皮质醇样本。除了对完整数据集进行描述性分析外,我们还对昼夜唾液皮质醇(即醒来后1 - 16小时)进行了混合效应生长曲线建模。皮质醇水平在一天中显著下降,且受到年龄和性别的影响。有趣的是,我们还发现采样季节有显著影响,春季昼夜皮质醇水平升高,秋季则降低。然而,大部分变异是由参与者间和研究间的变异成分造成的。基于这些分析,我们得出了一天中不同时间唾液皮质醇浓度的参考范围(液相色谱 - 串联质谱校准),并针对不同年龄组的男性和女性生成了更具体的参考范围。这一综合总结为唾液皮质醇提供了重要参考值,有助于基础科学家和临床医生解读与正常昼夜周期的偏差。