Isaksson Johan, Comasco Erika, Åslund Cecilia, Rehn Mattias, Tuvblad Catherine, Andershed Henrik, Nilsson Kent W
Department of Neuroscience, Uppsala University, 751 85 Uppsala, Sweden; Department of Women's and Children's Health, Pediatric Neuropsychiatry Unit, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND), Karolinska Institutet, 171 77 Stockholm, Sweden.
Department of Neuroscience, Uppsala University, 751 85 Uppsala, Sweden.
Psychoneuroendocrinology. 2016 Oct;72:196-204. doi: 10.1016/j.psyneuen.2016.07.206. Epub 2016 Jul 15.
The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.
编码FK506结合蛋白5（FKBP5）的基因被视为一个候选基因，用于研究负面生活事件如何与应激相关障碍（如抑郁症和焦虑症）的遗传易感性相互作用。鉴于FKBP5作为应激反应重要调节因子的作用，我们旨在研究FKBP5中的单核苷酸多态性（SNP）——在暴露于暴力与否的情况下——是否与抑郁和焦虑症状相关。收集了来自两个基于社区的青少年样本（n = 1705）和年轻人样本（n = 1800）的数据，这些数据涉及抑郁、焦虑、暴力暴露情况以及FKBP5基因型的评分。一种风险单倍型，包括FKBP5中七个常见SNP（rs3800373、rs9296158、rs7748266、rs1360780、rs9394309、rs9470080和rs4713916）的次要等位基因，在存在暴力的情况下，使女性而非男性的焦虑评分更高。暴露于暴力和女性性别与抑郁和焦虑的较高评分相关，但年轻人的抑郁评分除外，性别对其没有影响。抑郁评分与单倍型无关。这些发现可能与下丘脑-垂体-肾上腺（HPA）轴调节的差异以及女性对焦虑更高的易感性相对应。
