针对不均一核核糖核蛋白A1（hnRNPA1）的自身抗体导致“核糖体稳态”改变和神经退行性变；热带痉挛性截瘫作为进行性多发性硬化模型的遗留问题。

Autoantibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNPA1) cause altered 'ribostasis' and neurodegeneration; the legacy of HAM/TSP as a model of progressive multiple sclerosis.

作者信息

Levin Michael C, Lee Sangmin, Gardner Lidia A, Shin Yoojin, Douglas Joshua N, Salapa Hannah

机构信息

Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy/Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA; Neuroscience Institute, University of Tennessee Health Science Center, Memphis, TN, USA.

Veterans Administration Medical Center, Memphis, TN, USA; Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA.

出版信息

J Neuroimmunol. 2017 Mar 15;304:56-62. doi: 10.1016/j.jneuroim.2016.07.005. Epub 2016 Jul 17.

DOI:10.1016/j.jneuroim.2016.07.005

PMID:27449854

Abstract

Several years following its discovery in 1980, infection with human T-lymphotropic virus type 1 (HTLV-1) was shown to cause HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease biologically similar to progressive forms of multiple sclerosis (MS). In this manuscript, we review some of the clinical, pathological, and immunological similarities between HAM/TSP and MS with an emphasis on how autoantibodies to an RNA binding protein, heterogeneous nuclear ribonuclear protein A1 (hnRNP A1), might contribute to neurodegeneration in immune mediated diseases of the central nervous system.

摘要

1980年人类嗜T淋巴细胞病毒1型（HTLV-1）被发现，数年后，感染该病毒被证实会引发HTLV-1相关脊髓病/热带痉挛性截瘫（HAM/TSP），这是一种在生物学上与多发性硬化症（MS）的进展形式相似的疾病。在本手稿中，我们回顾了HAM/TSP与MS之间在临床、病理和免疫学方面的一些相似之处，重点探讨了针对一种RNA结合蛋白——不均一核核糖核蛋白A1（hnRNP A1）的自身抗体如何可能在中枢神经系统免疫介导疾病的神经退行性变中发挥作用。