Molecular switch of EZH2 in hypoxia.
作者信息
Mahara Sylvia, Chng Wee Joo, Yu Qiang
机构信息
a Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Agency for Science, Technology and Research , Biopolis , Singapore.
b Cancer Science Institute of Singapore, National University of Singapore , Singapore.
出版信息
Cell Cycle. 2016 Nov 16;15(22):3007-3008. doi: 10.1080/15384101.2016.1215699. Epub 2016 Jul 26.
Abstract
摘要
相似文献
1
Molecular switch of EZH2 in hypoxia.缺氧条件下EZH2的分子开关
Cell Cycle. 2016 Nov 16;15(22):3007-3008. doi: 10.1080/15384101.2016.1215699. Epub 2016 Jul 26.
2
HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.HIFI-α激活是Ezh2/PRC2在乳腺癌中矛盾作用的功能转换基础。
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3735-44. doi: 10.1073/pnas.1602079113. Epub 2016 Jun 14.
3
Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer.非经典EZH2在三阴性乳腺癌中对RelB进行转录激活。
PLoS One. 2016 Oct 20;11(10):e0165005. doi: 10.1371/journal.pone.0165005. eCollection 2016.
4
EZH2 in normal hematopoiesis and hematological malignancies.EZH2在正常造血和血液系统恶性肿瘤中的作用
Oncotarget. 2016 Jan 19;7(3):2284-96. doi: 10.18632/oncotarget.6198.
5
Structural Basis of the Interaction Between Ubiquitin Specific Protease 7 and Enhancer of Zeste Homolog 2.泛素特异性蛋白酶 7 与增强子结合锌指蛋白 2 相互作用的结构基础。
J Mol Biol. 2020 Feb 14;432(4):897-912. doi: 10.1016/j.jmb.2019.12.026. Epub 2019 Dec 20.
6
Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells.EZH2 和 P65 的相互作用参与了三氧化二砷诱导的人三阴性乳腺癌细胞的抗血管生成作用。
Cell Biol Toxicol. 2019 Aug;35(4):361-371. doi: 10.1007/s10565-018-09458-0. Epub 2019 Jan 5.
7
Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity.EZH2 多梳抑制复合物 2 亚基对于子宫上皮完整性是必需的。
Am J Pathol. 2019 Jun;189(6):1212-1225. doi: 10.1016/j.ajpath.2019.02.016. Epub 2019 Apr 5.
8
Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts.靶向EZH1和EZH2有助于miR-214-3p在心肌成纤维细胞中抑制纤维化相关基因。
Oncotarget. 2016 Nov 29;7(48):78331-78342. doi: 10.18632/oncotarget.13048.
9
Protein kinase A-mediated phosphorylation regulates STAT3 activation and oncogenic EZH2 activity.蛋白激酶 A 介导的磷酸化调节 STAT3 的激活和致癌 EZH2 的活性。
Oncogene. 2018 Jun;37(26):3589-3600. doi: 10.1038/s41388-018-0218-z. Epub 2018 Mar 26.
10
Aberrant expression of enhancer of zeste homologue 2, correlated with HIF-1α, refines relapse risk and predicts poor outcome for breast cancer.与缺氧诱导因子-1α相关的zeste同源物2增强子的异常表达，可优化复发风险并预测乳腺癌的不良预后。
Oncol Rep. 2014 Sep;32(3):1101-7. doi: 10.3892/or.2014.3322. Epub 2014 Jul 10.
引用本文的文献
1
How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia.氧合如何塑造免疫反应：生理性氧分压和病理性缺氧的新作用
Nat Rev Immunol. 2025 Mar;25(3):161-177. doi: 10.1038/s41577-024-01087-5. Epub 2024 Sep 30.
2
EZH2 Expression in Head-and-Neck Squamous Cell Cancer in Young Patients.EZH2 在年轻头颈鳞癌患者中的表达。
Int J Mol Sci. 2024 May 11;25(10):5250. doi: 10.3390/ijms25105250.
3
EZH2-Myc Hallmark in Oncovirus/Cytomegalovirus Infections and Cytomegalovirus' Resemblance to Oncoviruses.EZH2-Myc 标志在致癌病毒/巨细胞病毒感染和巨细胞病毒与致癌病毒的相似性。
Cells. 2024 Mar 19;13(6):541. doi: 10.3390/cells13060541.
4
Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets.催乳素受体信号调节小鼠胰岛妊娠特异性转录程序。
Endocrinology. 2019 May 1;160(5):1150-1163. doi: 10.1210/en.2018-00991.
5
Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression.NRF1、E2F4 和 MYC 转录因子之间的相互作用调节共同的靶基因，促进癌症的发生和发展。
Cell Oncol (Dordr). 2018 Oct;41(5):465-484. doi: 10.1007/s13402-018-0395-3. Epub 2018 Jul 25.
6
Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD/SIRT1/SUV39H1/H3K9me3 signaling pathway.去甲异波尔定，一种天然的 AhR 激动剂，通过靶向糖酵解及随后的 NAD/SIRT1/SUV39H1/H3K9me3 信号通路促进 Treg 分化并减轻结肠炎。
Cell Death Dis. 2018 Feb 15;9(3):258. doi: 10.1038/s41419-018-0297-3.
本文引用的文献
1
HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.HIFI-α激活是Ezh2/PRC2在乳腺癌中矛盾作用的功能转换基础。
Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3735-44. doi: 10.1073/pnas.1602079113. Epub 2016 Jun 14.
2
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.EZH2 抑制作为 EZH2 激活突变淋巴瘤的治疗策略。
Nature. 2012 Dec 6;492(7427):108-12. doi: 10.1038/nature11606. Epub 2012 Oct 10.
3
Comprehensive molecular portraits of human breast tumours.人类乳腺肿瘤的全面分子特征图谱。
Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23.
4
A complex Polycomb issue: the two faces of EZH2 in cancer.一个复杂的 Polycomb 问题：EZH2 在癌症中的双重面目。
Genes Dev. 2012 Apr 15;26(8):751-5. doi: 10.1101/gad.191163.112.
5
Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.EZH2 通过调控 NF-κB 靶基因表达在乳腺癌中具有组织特异性。
Mol Cell. 2011 Sep 2;43(5):798-810. doi: 10.1016/j.molcel.2011.08.011.
6
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.EZH2 通过激活 RAF1-β-连环蛋白信号促进乳腺肿瘤起始细胞的扩增。
Cancer Cell. 2011 Jan 18;19(1):86-100. doi: 10.1016/j.ccr.2010.10.035. Epub 2011 Jan 6.
7
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.核因子-κB通过对缺氧诱导因子-1α的转录调控将天然免疫与缺氧反应联系起来。
Nature. 2008 Jun 5;453(7196):807-11. doi: 10.1038/nature06905. Epub 2008 Apr 23.
Zotero 插件