A convergent approach to side-chain homologated derivatives of 1α,25-dihydroxyergocalciferol.
作者信息
Vinhas Silvia, Vázquez Socorro, Rodríguez-Borges J E, Sigüeiro Rita
机构信息
Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain; Department of Chemistry and Biochemistry, UCIBIO/REQUIMTE, Rua do Campo Alegre 687, 4169-007 Porto, Portugal.
Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain.
出版信息
J Steroid Biochem Mol Biol. 2017 Oct;173:83-85. doi: 10.1016/j.jsbmb.2016.07.015. Epub 2016 Jul 26.
As part of our program on search for vitamin D analogs with selective biological properties, such as low or negligible calcemic action, we describe here an efficient and versatile synthetic approach to derivatives of 1α,25-dihydroxyvitamin D with homologated side-chains and substitution at C24 for biological evaluation.
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