蔓越莓提取物通过减轻阿尔茨海默病线虫模型中的 Aβ 毒性发挥预防作用。

Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease.

机构信息

School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China; Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA.

Department of Biological Sciences, Clemson University, Clemson, SC 29634, USA; Institute for Engaged Aging, Clemson University, Clemson, SC 29634, USA.

出版信息

Chin J Nat Med. 2016 Jun;14(6):427-33. doi: 10.1016/S1875-5364(16)30039-5.

DOI:10.1016/S1875-5364(16)30039-5

PMID:27473960

Abstract

Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.

摘要

富含多酚的越橘提取物（CBE）通过缓解阿尔茨海默病（AD）模型线虫中β-淀粉样蛋白（Aβ）毒性来延迟瘫痪，具有显著效果。为了更有效地将 CBE 作为一种抗 AD 药物应用，我们试图确定预防性或治疗性效果对 CBE 的抗 AD 活性的贡献更显著。由于 Aβ毒性和记忆健康水平是 AD 的两个主要病理参数，在本研究中，我们比较了 CBE 在使用预防性和治疗性方案处理的 AD 模型线虫中对 Aβ毒性和记忆健康的影响。我们的结果表明，CBE 显著显示出预防功效，为进一步在哺乳动物中研究这些效果提供了依据。