Inoue Akihiro, Kohno Kanehisa, Fukumoto Shinya, Ozaki Saya, Ninomiya Satoko, Tomita Hitomi, Kamogawa Kenji, Okamoto Kensho, Ichikawa Haruhisa, Onoue Shinji, Miyazaki Hajime, Okuda Bungo, Iwata Shinji
Departments of Neurosurgery, Ehime Prefectural Central Hospital, Japan.
Departments of Neurosurgery, Ehime Prefectural Central Hospital, Japan.
Int J Surg Case Rep. 2016;26:108-12. doi: 10.1016/j.ijscr.2016.07.027. Epub 2016 Jul 27.
We report a patient treated successfully via endovascular surgery within 24h after intravenous thrombolysis using recombinant tissue plasminogen activator for acute cervical internal carotid artery occlusion.
A 68-year-old man was admitted to our hospital. Neurological examination revealed severe left-sided motor weakness. Magnetic resonance imaging showed no cerebral infarction, but magnetic resonance angiography revealed complete occlusion of the right internal carotid artery. Systemic intravenous injection of recombinant tissue plasminogen activator was performed within 4h after the onset. But, magnetic resonance angiography still revealed complete occlusion. Revascularization of the right cervical internal carotid artery was performed via endovascular surgery. The occluded artery was successfully recanalized using the Penumbra System(®) and stent placement at the origin of the internal carotid artery. Immediately after surgery, dual antiplatelet therapy (aspirin and clopidogrel) was initiated, and then cilostazol was added on the following day. Carotid ultrasonography and three-dimensional computed tomographic angiography at 14days revealed no further obstruction to flow.
When trying to perform emergency carotid artery stenting within 24h after intravenous recombinant tissue plasminogen activator administration, several issues require attention, such as the decisions regarding the type of stent and embolic protection device, the selection of antiplatelet therapy and the methods of preventing hyperperfusion syndrome.
Emergency carotid artery stenting for the acute internal carotid artery occlusion may be considered a safe procedure in preventing early stroke recurrence in selected patients.
我们报告了一例在静脉注射重组组织型纤溶酶原激活剂进行急性颈内动脉闭塞溶栓治疗后24小时内通过血管内手术成功治疗的患者。
一名68岁男性入住我院。神经系统检查显示左侧严重运动无力。磁共振成像未显示脑梗死,但磁共振血管造影显示右侧颈内动脉完全闭塞。发病后4小时内进行了全身静脉注射重组组织型纤溶酶原激活剂。但是,磁共振血管造影仍显示完全闭塞。通过血管内手术对右侧颈内动脉进行了血运重建。使用Penumbra System(®)成功再通闭塞动脉,并在颈内动脉起始处放置支架。手术后立即开始双联抗血小板治疗(阿司匹林和氯吡格雷),次日加用西洛他唑。14天时的颈动脉超声和三维计算机断层血管造影显示血流无进一步阻塞。
在静脉注射重组组织型纤溶酶原激活剂后24小时内尝试进行紧急颈动脉支架置入时,有几个问题需要注意,如支架和栓子保护装置类型的决策、抗血小板治疗的选择以及预防高灌注综合征的方法。
对于急性颈内动脉闭塞,紧急颈动脉支架置入术在预防特定患者早期卒中复发方面可能是一种安全的手术方法。