[The epidemiology of bloodstream infections in Fuxing Hospital in 2012 in Beijing].

OBJECTIVE

To investigate the etiology, clinical features and outcome of hospitalized patients with bloodstream infections (BSIs) in a tertiary hospital.

METHODS

Positive blood cultures were obtained from the microbiological laboratory in Fuxing Hospital, Capital Medical University from January 1, 2012 to December 31, 2012. BSIS events were identified and the epidemiology data were collected.

RESULTS

A total of 149 patients and 154 BSIs events were confirmed by pathogenic and clinical evidence. The in-patients' BSIs rate was 0.8% in our hospital in 2012. According to the disease entities of the first BSIs onset, 15 patients (10.1%) were from surgical departments, 83 patients (55.7%) from the medical departments, and 51 patients (34.2%) from ICU. Thirty-three patients (22.1%) were diagnosed as septic shock. Sixty-eight patients died during hospital stay. The in-hospital mortality rate was 45.6%. Among the 154 BSIs events, 125 (81.2%) were nosocomial and 29 (18.8%) were community-acquired. A total of 188 strains were isolated from all BSIs, including 106 strains of (56.4%) gram-negative bacilli, 67 (35.6%) strains of gram-positive bacteria, and 15 (8.0%) strains of fungi. One hundred and fifty-nine strains of bacteria (84.6%)were isolated from 125 events of hospital-acquired BSIs. Twenty-six strains of bacteria were from catheter related bloodstream infections (CRBSIs). In gram-negative BSIs, there were more enterobacteriaceae in community-acquired BSIs. More non-fermentative bacteria were found in hospital-acquired BSIs than in community-acquired ones. The distribution of gram-negative bacilli was quite different between surgical departments, non-surgical departments and ICU (P=0.049).

CONCLUSIONS

Pathogens of BSIs are quite different according to disease entities and where the patients are from. Local epidemiology of BSIs and distribution of related pathogens are helpful to physicians searching the optimal empirical antibiotics and improving the outcome.