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The effects of antidepressant treatments and lithium upon 5-HT1A receptor function.

作者信息

Goodwin G M

机构信息

MRC Brain Metabolism Unit, Edinburgh, U.K.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(3-4):445-51. doi: 10.1016/0278-5846(89)90132-2.

DOI:10.1016/0278-5846(89)90132-2
PMID:2748872
Abstract
  1. The functional effects of the 5-HT1A receptor selective ligand, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) can be divided into effects mediated by presynaptic (somato-dendritic) autoreceptors and postsynaptic receptors. Hypothermic responses in the mice and rat reflect presynaptic effects. Stereotypic motor responses in the rat reflect postsynaptic function. 2) These functional models of 5-HT1A receptor activity have been used to examine the effects of different antidepressant treatments and lithium during acute (24h) and chronic (14 day) administration. 3) Presynaptic 5-HT1A-mediated hypothermia is attenuated by chronic treatment with amitriptyline, desipramine, zimeldine, high dose mianserin, tranylcypromine, lithium and repeated electroconvulsive shock (ECS). Thus, all these treatments may increase tolerance to increased release of 5-HT. 4) Postsynaptic 5-HT1A-mediated motor effects are attenuated by desipramine, zimeldine and ECS but enhanced by lithium. 5) The 5-HT1A receptor appears to be an important locus for the actions of antidepressant treatments and lithium.
摘要

相似文献

1
The effects of antidepressant treatments and lithium upon 5-HT1A receptor function.
Prog Neuropsychopharmacol Biol Psychiatry. 1989;13(3-4):445-51. doi: 10.1016/0278-5846(89)90132-2.
2
Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat.电休克和抗抑郁药物对8-OH-DPAT在大鼠中产生的5-HT1A受体介导的体温过低和血清素综合征的减弱作用。
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3
Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock.抗抑郁药物和电休克减弱小鼠中突触前5-羟色胺受体介导的反应。
Nature. 1985;317(6037):531-3. doi: 10.1038/317531a0.
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The effect of chronic administration of antidepressants and electroconvulsive shock on the 5-HT1A receptor mediated hypothermic response induced by 8-OH-DPAT in the rat.
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):409-16. doi: 10.1016/0278-5846(94)90072-8.
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Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors.突触后5-HT1A受体介导8-OH-DPAT对小鼠的抗抑郁样作用。
Br J Pharmacol. 1993 Mar;108(3):669-77. doi: 10.1111/j.1476-5381.1993.tb12859.x.
6
Selective 5-HT1A and 5-HT2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments.大鼠中5-羟色胺1A和5-羟色胺2受体介导的促肾上腺皮质激素释放：重复抗抑郁治疗的影响
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The effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive shock.对小鼠急性和反复给予T3对其大脑中5-HT1和5-HT2功能的影响及其对反复电惊厥休克作用的影响。
Neuropharmacology. 1988 Dec;27(12):1239-48. doi: 10.1016/0028-3908(88)90026-3.
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Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat.长期给予抗抑郁治疗对5-羟色胺系统突触前和突触后的修饰作用。大鼠体内电生理学研究。
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Chronic lithium treatment enhances the postsynaptic 5-HT1A receptor-mediated 5-HT behavioral syndrome induced by 8-OH-DPAT in rats via catecholaminergic systems.长期锂盐治疗通过儿茶酚胺能系统增强8-羟基二丙胺基四氢萘（8-OH-DPAT）诱导的大鼠突触后5-羟色胺1A（5-HT1A）受体介导的5-羟色胺行为综合征。
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The enhancement by lithium of the 5-HT1A mediated serotonin syndrome produced by 8-OH-DPAT in the rat: evidence for a post-synaptic mechanism.锂增强大鼠中由8-OH-DPAT产生的5-HT1A介导的血清素综合征：突触后机制的证据。
Psychopharmacology (Berl). 1986;90(4):488-93. doi: 10.1007/BF00174066.

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Alpha-2 adrenergic-induced changes in rectal temperature in adult and 13-day old rats following acute and repeated desipramine administration.急性和重复给予地昔帕明后，α-2肾上腺素能诱导成年大鼠和13日龄大鼠直肠温度的变化。
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Effects of repeated mild stress and two antidepressant treatments on the behavioral response to 5HT1C receptor activation in rats.
重复轻度应激及两种抗抑郁治疗对大鼠5HT1C受体激活后行为反应的影响。
Psychopharmacology (Berl). 1993;110(1-2):140-4. doi: 10.1007/BF02246963.
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Effects of glucocorticoids on 5-HT1A presynaptic function in the mouse.糖皮质激素对小鼠5-羟色胺1A（5-HT1A）突触前功能的影响。
Psychopharmacology (Berl). 1994 Mar;114(2):360-4. doi: 10.1007/BF02244859.
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No alterations in the 5-HT1A-mediated inhibition of forskolin-stimulated adenylate cyclase activity in the hippocampal membranes from rats chronically treated with lithium or antidepressants.长期用锂盐或抗抑郁药治疗的大鼠海马膜中，5-羟色胺1A介导的对福斯高林刺激的腺苷酸环化酶活性的抑制作用无改变。
J Neural Transm Gen Sect. 1991;86(2):85-96. doi: 10.1007/BF01250570.
6
Platelet adenylate cyclase activity in depression and after clomipramine and lithium treatment: relation to serotonergic function.抑郁症患者及经氯米帕明和锂盐治疗后的血小板腺苷酸环化酶活性：与血清素能功能的关系。
Psychopharmacology (Berl). 1992;109(1-2):231-4. doi: 10.1007/BF02245505.
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Flesinoxan shows antidepressant activity in a DRL 72-s screen.氟西诺生在72秒固定比率递减（DRL）筛选试验中显示出抗抑郁活性。
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