Bjelica Artur, Bjelanović Jelena, Milić Natasa, Mladenović Segedi Ljiljana, Ilić Đorde, Dimitrijević Jelena
Med Pregl. 2016 Jan-Feb;69(1-2):25-30. doi: 10.2298/mpns1602025b.
Polycystic ovary syndrome is the most frequent endocrine disturbance in the reproductive period of women's life and the most frequent cause of anovulatory infertility. Ovulation and pregnancy in patients having polycystic ovary syndrome may be a result of a wide range of therapeutic options, and the treatment assumes a gradual approach--from simple noninvasive to expensive and demanding procedures.
A systematic literature survey concerning the efficiency of particular ovulation induction methods in respect of the reproductive outcome was carried out with the aim of establishing the algorithm for ovulation induction in infertile patients having polycystic ovary syndrome. The search was confined to clinical investigations performed on human subjects, reported in English in the period from the beginning of 2010 to June of 2014.
As a conclusion of this systematic survey of the efficiency of ovulation induction methods, which confirms and supplements the knowledge in this field, it is possible to form the algorithm for ovulation induction in infertile patients having polycystic ovary syndrome, consisting of the following subsequent steps: 1) modification of life style, 2) induction with clomiphene citrate 3) use of metformin, 4) use ofaromatase inhibitors, 5) application ofgonadotropins and laparoscopic ovarian drilling--as a second-line treatment, and 6) assisted reproductive techniques.
多囊卵巢综合征是女性生育期最常见的内分泌紊乱疾病，也是无排卵性不孕的最常见原因。多囊卵巢综合征患者的排卵和受孕可能得益于多种治疗方案，治疗采用循序渐进的方式——从简单的非侵入性方法到昂贵且要求较高的程序。
针对特定促排卵方法对生殖结局的有效性进行了系统的文献调查，目的是为多囊卵巢综合征不孕患者建立促排卵算法。检索仅限于2010年初至2014年6月期间以英文报道的对人类受试者进行的临床研究。
作为本次促排卵方法有效性系统调查的结论，该调查证实并补充了该领域的知识，有可能形成多囊卵巢综合征不孕患者的促排卵算法，包括以下后续步骤：1）生活方式调整，2）枸橼酸氯米芬诱导，3）使用二甲双胍，4）使用芳香化酶抑制剂，5）应用促性腺激素和腹腔镜卵巢打孔——作为二线治疗，以及6）辅助生殖技术。
