非糖尿病高血压患者血清组织蛋白酶 D 水平与颈动脉内膜中层厚度的关系。

The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients.

机构信息

Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Department of Radiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

出版信息

Turk J Med Sci. 2016 Jan 5;46(1):13-7. doi: 10.3906/sag-1410-55.

DOI:10.3906/sag-1410-55

PMID:27511327

Abstract

BACKGROUND/AIM: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients.

MATERIALS AND METHODS

This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery.

RESULTS

Mean CIMT value was 0.76 ± 0.15 mm, and median cathepsin D level was 190.3 (12.8-2681.3) ng/mL. A marked positive correlation was found between cathepsin D levels and CIMT (r = 0.331, P = 0.04). In multivariate linear regression analysis, cathepsin D, albumin levels, and the duration of hypertension were significant predictors of CIMT (P = 0.017, P = 0.008, and P = 0.043, respectively).

CONCLUSIONS

Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.

摘要

背景/目的：我们旨在研究高血压患者颈动脉内膜中层厚度（CIMT）与血清组织蛋白酶 D 水平之间的关系。

材料与方法

这是一项横断面研究，纳入了 74 名高血压患者（22 名男性和 52 名女性，平均年龄为 51.86±11.75 岁）。采用酶联免疫吸附试验测定血清组织蛋白酶 D 水平。从 3 个不同部位测量 CIMT：右颈总动脉、左颈总动脉、颈动脉分叉处和颈内动脉前 2cm 处。通过平均每个颈动脉 3 次测量的结果来计算平均 CIMT。

结果

平均 CIMT 值为 0.76±0.15mm，中位组织蛋白酶 D 水平为 190.3（12.8-2681.3）ng/mL。组织蛋白酶 D 水平与 CIMT 之间存在显著正相关（r=0.331，P=0.04）。在多元线性回归分析中，组织蛋白酶 D、白蛋白水平和高血压病程是 CIMT 的显著预测因素（P=0.017、P=0.008 和 P=0.043）。