Lennartsson Anna-Karin, Theorell Töres, Kushnir Mark M, Jonsdottir Ingibjörg H
Institute of Stress Medicine, Göteborg, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
Biol Psychol. 2016 Oct;120:28-34. doi: 10.1016/j.biopsycho.2016.08.003. Epub 2016 Aug 12.
The regenerative hormone DHEA-S was measured in 122 patients with clinical burnout during their first year of treatment. Relations between change of DHEA-S levels and development in health were investigated. About half of the patients exhibited increased DHEA-S levels during the year, while the other half exhibited decreased levels. There was no difference in burnout symptoms or associated health status at baseline between subsequent DHEA-S increasing and DHEA-S decreasing groups. Greater reduction in the burnout symptoms was observed in patients in who DHEA-S levels increased during the year, than in the patients in who DHEA-S levels decreased. Relative change of DHEA-S and direction of the change during the year both predicted burnout symptoms at the end of the year. In addition, patients with increased DHEA-S levels had better self-rated health, vitality and well-being. Our data suggest that changes in DHEA-S are associated with prognosis for the outcome in burnout patients.
在122例临床倦怠患者治疗的第一年,对其再生激素硫酸脱氢表雄酮(DHEA-S)进行了测量。研究了DHEA-S水平变化与健康状况发展之间的关系。约一半患者在这一年中DHEA-S水平升高,而另一半患者水平降低。随后DHEA-S升高组和DHEA-S降低组在基线时的倦怠症状或相关健康状况并无差异。与DHEA-S水平降低的患者相比,DHEA-S水平在这一年中升高的患者倦怠症状减轻更为明显。DHEA-S的相对变化以及这一年中的变化方向均能预测年末的倦怠症状。此外,DHEA-S水平升高的患者自我评定的健康、活力和幸福感更好。我们的数据表明,DHEA-S的变化与倦怠患者的预后相关。