50例原发性胃肠道非霍奇金淋巴瘤临床预后分析

[Analysis of Clinical Prognosis of 50 Cases of Primary Gastrointestinal Non-Hodgkin's Lymphoma].

作者信息

Zheng Jian, Gao Hong, Hong Cheng-Yu, Bai Xiao-Ru, Lin Xue-Jun, Li Xiao-Ling

机构信息

Department of Internal Medicine, Liaoning Cancer Hospital & Institute, Chinese Medical University, Shenyang 110042, Liaoning Province, China.

Department of Radiology, Liaoning Cancer Hospital & Institute, Chinese Medical University, Shenyang 110042, Liaoning Province, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Aug;24(4):1051-5. doi: 10.7534/j.issn.1009-2137.2016.04.017.

DOI:10.7534/j.issn.1009-2137.2016.04.017

PMID:27531773

Abstract

OBJECTIVE

To analyze the clinical pathologic characteristics, diagnosis, treatment and outcome of patients with primary gastrointestinal non-Hodgkin's lymphoma(PGI-NHL).

METHODS

The clinical and pathological features of 50 cases of PGI-NHL were analyzed retrospectively, the Kaplan-Meier was applied to estimate the survival time of all the patients.

RESULTS

The median age of patients was 58 years old, the cases of male patient were more than that of femal. The main clinical symptoms included pain and discomfort. The patients of Ⅰ-Ⅱstage accounted for 66%, DLBCL was most common. The clinical and pathological features were not significantly different between gastric and intestinal lymphoma. In 58% of the patients, surgery was the first choice for treatment. The median survival time was 74 months. The OS rates at 1-, 3- and 5-year were 78%, 65.9% and 61.8% respectively. Log-rank univariate analysis showed that age, sex, ECOG score, B symptoms, disease location and treatment methods all did not relate with OS, however, IPI, stage, LDH, cell phenotype and pathological type closely related with the OS.

CONCLUSION

As lacking characteristic clinical manifestations of PGI-NHL, the DLBCL is the most common type. The prognosis of B cell lymphoma is significantly better than that of T cell lymphoma. The prognosis of PTCL is the worst.

摘要

目的

分析原发性胃肠道非霍奇金淋巴瘤（PGI-NHL）患者的临床病理特征、诊断、治疗及预后。

方法

回顾性分析50例PGI-NHL患者的临床及病理特征，采用Kaplan-Meier法估计所有患者的生存时间。

结果

患者中位年龄58岁，男性病例多于女性。主要临床症状为疼痛和不适。Ⅰ-Ⅱ期患者占66%，弥漫大B细胞淋巴瘤（DLBCL）最为常见。胃淋巴瘤和肠淋巴瘤的临床及病理特征无明显差异。58%的患者治疗首选手术。中位生存时间为74个月。1年、3年和5年总生存率分别为78%、65.9%和61.8%。Log-rank单因素分析显示，年龄、性别、美国东部肿瘤协作组（ECOG）评分、B症状、病变部位及治疗方法均与总生存无关，然而，国际预后指数（IPI）、分期、乳酸脱氢酶（LDH）、细胞表型及病理类型与总生存密切相关。