趋化因子在口腔癌微环境中增强促肿瘤活性，这为治疗方案提供了一个迫切需要的策略。

Chemokines accentuating protumoral activities in oral cancer microenvironment possess an imperious stratagem for therapeutic resolutions.

作者信息

Panda Swagatika, Padhiary Subrat Kumar, Routray Samapika

机构信息

Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751030, India.

Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar 751030, India.

出版信息

Oral Oncol. 2016 Sep;60:8-17. doi: 10.1016/j.oraloncology.2016.06.008. Epub 2016 Jun 29.

DOI:10.1016/j.oraloncology.2016.06.008

PMID:27531867

Abstract

Chemokines, the chemotactic cytokines have established their role in tumorigenesis and tumor progression. Studies, which explored their role in oral cancer for protumoral activity, point towards targeting chemokines for oral squamous cell carcinoma therapy. The need of the hour is to emphasize/divulge in the activities of chemokine ligands and their receptors in the tumor microenvironment for augmentation of such stratagems. This progressing sentience of chemokines and their receptors has inspired this review which is an endeavour to comprehend their role as an aid in accentuating hallmarks of cancer and targeted therapy.

摘要

趋化因子，即趋化性细胞因子，已在肿瘤发生和肿瘤进展中确立了其作用。探索它们在口腔癌中促肿瘤活性作用的研究表明，可将趋化因子作为口腔鳞状细胞癌治疗的靶点。当前迫切需要强调/揭示趋化因子配体及其受体在肿瘤微环境中的活性，以增强此类策略。对趋化因子及其受体不断深入的认识激发了本综述，旨在努力理解它们在强化癌症特征和靶向治疗方面的辅助作用。