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药物治疗期间癌症细胞间协同相互作用效应的数学模型

Mathematical model of the effect of intercellular cooperative interactions in cancer during drug therapy.

作者信息

Kaddi Chanchala D, Wang May D

机构信息

Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.

Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA (phone: 404-385-5059).

出版信息

Annu ORNL Biomed Sci Eng Cent Conf. 2013 May;2013. doi: 10.1109/BSEC.2013.6618486.

DOI:10.1109/BSEC.2013.6618486
PMID:27532060
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4983431/
Abstract

We present an agent-based model of head and neck cancer cell population dynamics that investigates the effect of cooperative interactions between individual cancer cells during the course of cytotoxic drug treatment. A model of cooperative behavior based on the Lotka-Volterra competition equations is combined with a model of drug resistance and response. Predictions regarding the individual and combination effects of cooperation and drug treatment qualitatively match experimental observations from the literature.

摘要

我们提出了一种基于主体的头颈癌细胞群体动力学模型，该模型研究了细胞毒性药物治疗过程中单个癌细胞之间合作相互作用的影响。基于Lotka-Volterra竞争方程的合作行为模型与耐药性和反应模型相结合。关于合作与药物治疗的个体及联合效应的预测与文献中的实验观察结果在性质上相符。

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