在先前未经治疗与经局灶性激光治疗的中心性浆液性脉络膜视网膜病变患者眼中，脉络膜新生血管膜对抗血管内皮生长因子治疗的视觉预后差异。

Variation in Visual Outcome to Anti-Vascular Endothelial Growth Factors in Choroidal Neovascular Membrane Developing in Eyes with Previously Untreated Versus Focal Laser-Treated Central Serous Chorioretinopathy.

作者信息

Roy Rupak, Saurabh Kumar, Das Debmalya, Panigrahi Pradeep Kumar, Das Sudipta, Pal Swakshyar Saumya, Jain Amit

机构信息

a Department of Vitreoretina , Sankara Nethralaya , Kolkata , West Bengal , India.

b Shri Bhagwan Mahavir Vitreoretina Services , Sankara Nethralaya , Chennai , Tamil Nadu , India.

出版信息

Semin Ophthalmol. 2017;32(6):781-786. doi: 10.1080/08820538.2016.1182556. Epub 2016 Aug 17.

DOI:10.1080/08820538.2016.1182556

PMID:27533737

Abstract

PURPOSE

To report the visual outcome in choroidal neovascular membrane developing (CNVM) in eyes with central serous chorioretinopathy (CSCR) with our without prior focal laser.

METHODS

A retrospective case series of eyes with CNVM secondary to CSCR treated with intravitreal anti-VEGF.

RESULTS

Ten eyes of nine patients of CNVM with CSCR who underwent intravitreal anti-VEGF injections were analyzed. Five eyes had CNVM without prior laser photocoagulation, and five eyes developed CNVM after laser photocoagulation for CSCR. Intravitreal injection bevacizumab was given in five eyes and ranibizumab in five eyes. The lasered group had significantly shorter duration of the disease, fewer injections given, and better visual acuity at final follow-up (P <0.05). None had any recurrences of either CSCR or CNVM until the last follow-up.

CONCLUSION

CNVM in CSCR with prior history of focal laser had better outcome than that developed de novo, without prior history of laser.

摘要

目的

报告伴有或不伴有先前局部激光治疗的中心性浆液性脉络膜视网膜病变（CSCR）患者眼中脉络膜新生血管膜（CNVM）形成后的视力结果。

方法

一项关于接受玻璃体内抗VEGF治疗的继发于CSCR的CNVM患者的回顾性病例系列研究。

结果

分析了9例接受玻璃体内抗VEGF注射治疗的CSCR合并CNVM患者的10只眼。5只眼的CNVM未经先前的激光光凝治疗，5只眼在CSCR激光光凝治疗后出现CNVM。5只眼给予玻璃体内注射贝伐单抗，5只眼给予雷珠单抗。接受激光治疗的组疾病持续时间明显更短，注射次数更少，末次随访时视力更好（P<0.05）。直至最后一次随访，无一例CSCR或CNVM复发。