Xiao L L, Zhou Y, Cui X Q, Huang X J, Yuan J, Chen W H
Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2016 Aug 6;50(8):680-8. doi: 10.3760/cma.j.issn.0253-9624.2016.08.004.
OBJECTIVE: To investigate the association between levels of 23 urinary metals and lung function, and explore their does-response relationships in the general population of Wuhan province, China. METHODS: This was a cross-sectional study that enrolled volunteers from two communities of Wuhan between April and May 2011. All volunteers had resided in Wuhan for at least 5 years. Information from questionnaires and physical examinations were collected and lung function was assessed. Data from 2 540 volunteers were included. Urinary levels of 23 metals were measured by inductively coupled plasma mass spectrometry (ICP-MS). The relationship between urinary metals and lung function was analyzed with single and multiple regression models. RESULTS: The mean age of the study population was 52.8 years. Mean levels of urinary metals, after adjustment for creatinine, including cobalt, copper, zinc, nickel, antimony and barium were 0.02, 0.68, 23.80, 0.20, 0.10, 0.34 and 0.26 μg/g creatinine, respectively. There were significant concentration-response relationships between increases in some urinary metals and reduced lung function. Single-metal regression models demonstrated that for each 1-unit increase in urinary levels of cobalt, lncopper, lnzinc, lnantimony, there was a reduction in forced vital capacity (FVC) of 0.091 L (95%CI: -0.155--0.027), 0.101 L (95%CI: -0.178--0.025), 0.094 L (95%CI: -0.172--0.027) and 0.118 L (95% CI: -0.203--0.033), respectively. Each 1-unit-increase in urinary lncobalt, lnnickel, lnstrontium, lnantimony, lnthallium, lnlead was associated with a reductions in forced expiratory volume in 1 sec (FEV1) of 0.070 L (95%CI: -0.124--0.016), 0.063 L (95%CI: -0.118--0.007), 0.063 L (95%CI: -0.124--0.002), 0.092 L (95%CI: -0.164--0.020), 0.055 L (95%CI: -0.105--0.005), 0.081 L (95%CI: -0.148--0.014), and 0.097 L (95% CI: -0.151--0.042), respectively. With respect to metal co-exposure, FVC was significantly associated with elevated urinary levels of cobalt, Cu and Sb, with reductions of 0.126 L (95%CI: 0.037-0.216) and 0.106 L (95% CI: 0.021-0.192), respectively, while FEV1 was significantly associated with elevated urinary Co, Sb, Ba and Pb, with reductions of 0.067 L (95% CI: -0.129--0.005), 0.142 L (95% CI: -0.247--0.037), 0.073 L (95% CI: -0.142--0.003) and 0.104 L (95% CI: -0.175--0.034), respectively. CONCLUSIONS: Certain urinary metals were potentially associated, in a dose-dependent manner, with reduced lung function in the general population. Co-exposure to metals had stimulative and anti-stimulative effects on lung function.
目的：调查23种尿金属水平与肺功能之间的关联，并在中国湖北省武汉市普通人群中探索它们的剂量-反应关系。 方法：这是一项横断面研究，于2011年4月至5月招募了来自武汉两个社区的志愿者。所有志愿者均在武汉居住至少5年。收集问卷和体格检查信息，并评估肺功能。纳入了2540名志愿者的数据。采用电感耦合等离子体质谱法（ICP-MS）测量23种金属的尿水平。用单因素和多因素回归模型分析尿金属与肺功能之间的关系。 结果：研究人群的平均年龄为52.8岁。校正肌酐后，尿金属的平均水平，包括钴、铜、锌、镍、锑和钡，分别为0.02、0.68、23.80、0.20、0.10、0.34和0.26μg/g肌酐。一些尿金属水平升高与肺功能降低之间存在显著的浓度-反应关系。单金属回归模型显示，尿钴、ln铜、ln锌、ln锑水平每增加1个单位，用力肺活量（FVC）分别降低0.091L（95%CI：-0.155--0.027）、0.101L（95%CI：-0.178--0.025）、0.094L（95%CI：-0.172--0.027）和0.118L（95%CI：-0.203--0.033）。尿ln钴、ln镍、ln锶、ln锑、ln铊、ln铅每增加1个单位，1秒用力呼气量（FEV1）分别降低0.070L（95%CI：-0.124--0.016）、0.063L（95%CI：-0.118--0.007）、0.063L（95%CI：-0.124--0.002）、0.092L（95%CI：-0.164--0.020）、0.055L（95%CI：-0.105--0.005）、0.081L（95%CI：-0.148--0.014）和0.097L（95%CI：-0.151--0.042）。关于金属共同暴露，FVC与尿钴、铜和锑水平升高显著相关，分别降低0.126L（95%CI：0.037-0.216）和0.106L（95%CI：0.021-0.192），而FEV1与尿钴、锑、钡和铅水平升高显著相关，分别降低0.067L（95%CI：-0.129--0.005）、0.142L（95%CI：-0.247--0.037）、0.073L（95%CI：-0.142--0.003）和0.104L（95%CI：-0.175--0.034）。 结论：某些尿金属可能以剂量依赖的方式与普通人群肺功能降低有关。金属共同暴露对肺功能有刺激和反刺激作用。
Zhonghua Yu Fang Yi Xue Za Zhi. 2016-8-6
Zhonghua Yu Fang Yi Xue Za Zhi. 2016-8-6
Zhonghua Yu Fang Yi Xue Za Zhi. 2016-8-6
Environ Sci Pollut Res Int. 2023-5
Environ Sci Pollut Res Int. 2019-1-6
Respir Res. 2018-11-6
Int J Environ Res Public Health. 2022-2-13
Zotero 插件