Katsidzira Leolin, Chokunonga Eric, Gangaidzo Innocent T, Rusakaniko Simbarashe, Borok Margaret, Matsena-Zingoni Zvifadzo, Thomson Sandie, Ramesar Raj, Matenga Jonathan A
Department of Medicine, College of Health Sciences, University of Zimbabwe, P.O. Box A178, Avondale, Harare, Zimbabwe; Division of Gastroenterology, Department of Medicine, University of Cape Town, Cape Town, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa.
Zimbabwe National Cancer Registry, P.O. Box A449, Avondale, Harare, Zimbabwe.
Cancer Epidemiol. 2016 Oct;44:96-100. doi: 10.1016/j.canep.2016.08.001. Epub 2016 Aug 16.
Data on colorectal cancer (CRC) in sub-Saharan Africa is mainly based on hospital series which suggest low incidence and frequent early onset cancers. This study characterises colorectal cancer in a population-based cancer registry in Zimbabwe.
Cases of CRC recorded by the Zimbabwe National Cancer Registry between 2003 and 2012 were analysed. Demographic and pathological characteristics were compared according to ethnicity and age. Trends in age standardised incidence rates (ASR) were determined.
There were 886 and 216 cases of CRC among black Africans and Caucasians respectively, and 26% of the black Africans were younger than 40 years. Signet ring cell carcinomas were more common among black Africans compared to Caucasians (4% vs 1%, p=0.027). ASR increased by 1.9%/year and 3.9%/year among black African males and females respectively.
CRC incidence is rising among black Africans and has unique demographic and pathological characteristics.
撒哈拉以南非洲地区结直肠癌（CRC）的数据主要基于医院病例系列，显示发病率较低且癌症多为早期发病。本研究对津巴布韦一个基于人群的癌症登记处的结直肠癌特征进行了描述。
分析了津巴布韦国家癌症登记处在2003年至2012年间记录的结直肠癌病例。根据种族和年龄比较了人口统计学和病理特征。确定了年龄标准化发病率（ASR）的趋势。
非洲黑人中有886例结直肠癌病例，白种人中有216例，26%的非洲黑人年龄小于40岁。与白种人相比，印戒细胞癌在非洲黑人中更为常见（4%对1%，p = 0.027）。非洲黑人男性和女性的ASR分别以每年1.9%和3.9%的速度上升。
非洲黑人中的结直肠癌发病率正在上升，且具有独特的人口统计学和病理特征。
