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肯塔基大学医学中心的颌骨放射性骨坏死

Osteoradionecrosis of the jaw bones at the University of Kentucky Medical Center.

作者信息

Patel P, Raybould T, Maruyama Y

出版信息

J Ky Med Assoc. 1989 Jul;87(7):327-31.

PMID:2754311
Abstract

There is disagreement over the management of teeth in irradiated head and neck cancer patients. Some oral surgeons support preirradiation extraction; others favor maintaining teeth. Before 1974, The University of Kentucky Department of Radiation Medicine found osteoradionecrosis (ORN) of the jaw in 10.9% of 220 irradiated cancer patients. After a program of oral care was instituted, the incidence declined to 2.7%. Of 109 patients who received radiotherapy between 1976 and 1985, only three (2.7%) developed ORN of the mandible. There was also a reduction in patients treated with interstitial therapy during this time. A review of the most recent experiences shows that, with present management methods at the University of Kentucky, ORN is not a significant problem. Of 30 patients treated in 1986, only one had ORN, and this was of the maxilla. Post-irradiation extractions were not identified as a significant risk for necrosis. Hyperbaric oxygen is used as a treatment for persistent ORN.

摘要

对于接受过放射治疗的头颈癌患者的牙齿处理,存在不同意见。一些口腔外科医生支持放疗前拔牙;另一些则倾向于保留牙齿。1974年之前,肯塔基大学放射医学系在220例接受放疗的癌症患者中发现10.9%的患者发生颌骨放射性骨坏死(ORN)。在实施口腔护理计划后,发病率降至2.7%。在1976年至1985年间接受放疗的109例患者中,只有3例(2.7%)发生下颌骨ORN。在此期间,接受间质治疗的患者也有所减少。对最新经验的回顾表明,按照肯塔基大学目前的处理方法,ORN并非一个严重问题。1986年接受治疗的30例患者中,只有1例发生ORN,且为上颌骨。放疗后拔牙未被认定为发生坏死的重大风险因素。高压氧被用作持续性ORN的治疗方法。

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