Hassan Muhannad, Solanki Sharaddha, Kassouf Wassim, Kanber Yonca, Caglar Derin, Auger Manon, Brimo Fadi
From the Department of Pathology.
Department of Urology, McGill University and McGill University Health Center, Montreal, Canada.
Am J Clin Pathol. 2016 Sep;146(3):384-90. doi: 10.1093/ajcp/aqw127.
We assessed the performance of urine cytology using the Paris System for Reporting Urine Cytology (PSRUC) in comparison to our current system.
In total, 124 specimens with histologic correlation were reviewed and assigned to the PSRUC categories: benign, atypical urothelial cells (AUCs), suspicious for high-grade urothelial carcinoma (SHGUC), and high-grade urothelial carcinoma (HGUC). Original cytological diagnoses were recorded.
Fewer cases were given an AUC diagnosis using the PSRUC in comparison to the original diagnoses (26% vs 39%), while the association of AUCs with subsequent HGUC increased from 33% to 53% with the PSRUC. Using the PSRUC resulted in a higher number of low-grade carcinomas assigned to the benign (40%) rather than the AUC (22%) category. The performance of SHGUC/HGUC diagnoses was similar in both systems (predictive value = 94%).
The PSRUC seems to improve the performance of urine cytology by limiting the AUC category to cases that are more strongly associated with HGUC.
我们评估了使用巴黎尿液细胞学报告系统（PSRUC）的尿液细胞学检查与我们当前系统相比的性能。
总共回顾了124例具有组织学相关性的标本，并将其归入PSRUC类别：良性、非典型尿路上皮细胞（AUC）、高度怀疑尿路上皮癌（SHGUC）和高度尿路上皮癌（HGUC）。记录原始细胞学诊断结果。
与原始诊断相比，使用PSRUC诊断为AUC的病例较少（26%对39%），而使用PSRUC时，AUC与随后的HGUC的关联从33%增加到53%。使用PSRUC导致更多的低级别癌被归入良性（40%）而非AUC（22%）类别。两个系统中SHGUC/HGUC诊断的性能相似（预测值=94%）。
PSRUC似乎通过将AUC类别限制在与HGUC关联更强的病例中，提高了尿液细胞学检查的性能。
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