铑催化的苯甲酰胺与 1,3-二烯的氧化 C-H 烯丙基化反应，通过烯丙基到烯丙基 1,4-Rh(III)迁移。
Rhodium-Catalyzed Oxidative C-H Allylation of Benzamides with 1,3-Dienes by Allyl-to-Allyl 1,4-Rh(III) Migration.
机构信息
School of Chemistry, University of Nottingham , University Park, Nottingham NG7 2RD, United Kingdom.
出版信息
J Am Chem Soc. 2016 Sep 21;138(37):12252-7. doi: 10.1021/jacs.6b06884. Epub 2016 Sep 6.
The Rh(III)-catalyzed oxidative C-H allylation of N-acetylbenzamides with 1,3-dienes is described. The presence of allylic hydrogens cis to the less substituted alkene of the 1,3-diene is important for the success of these reactions. With the assistance of reactions using deuterated 1,3-dienes, a proposed mechanism is provided. The key step is postulated to be the first reported examples of allyl-to-allyl 1,4-Rh(III) migration.
本文描述了 Rh(III)催化的 N-乙酰苯甲酰胺与 1,3-二烯的氧化 C-H 烯丙基化反应。1,3-二烯中烯丙基氢位于取代较少的烯烃的顺式位置对于这些反应的成功至关重要。通过使用氘代 1,3-二烯的反应，提供了一个提出的反应机制。关键步骤被假定为首次报道的烯丙基至烯丙基 1,4-Rh(III)迁移的实例。
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