Mahmoudi M J, Taghvaei M, Harsini S, Amirzargar A A, Hedayat M, Mahmoudi M, Nematipour E, Farhadi E, Esfahanian N, Sadr M, Nourijelyani K, Rezaei N
Bratisl Lek Listy. 2016;117(7):367-70. doi: 10.4149/bll_2016_072.
Proinflammatory cytokines have been known to play a considerable part in the pathomechanisms of chronic heart failure (CHF). Given the importance of proinflammatory cytokines in the context of the failing heart, we assessed whether the polymorphisms of interleukin (IL)-1 gene cluster, including IL-1α, IL-1β, and IL-1 receptor antagonist (IL-1RA) and IL-1R gene are predictors of CHF due to ischemic heart disease.
Forty- three patients with ischemic heart failure were recruited in this study as patients group and compared with 140 healthy unrelated control subjects. Using polymerase chain reaction with sequence-specific primers method, the allele and genotype frequency of 5 single nucleotide polymorphisms (SNPs) within the IL-1α (-889), IL-1β (-511, +3962), IL-1R (psti 1970), and IL-1RA (mspa1 11100) genes were determined.
The frequency of the IL-1β -511/C allele was significantly higher in the patient group compared to that in the control group (p = 0.031). The IL-1β (-511) C/C genotype was significantly overrepresented in patients compared to controls (p = 0.022).
Particular allele and genotype in IL-1β gene were overrepresented in patients with ischemic heart failure, possibly affecting the individual susceptibility to this disease (Tab. 1, Ref. 27).
已知促炎细胞因子在慢性心力衰竭（CHF）的发病机制中起重要作用。鉴于促炎细胞因子在心脏衰竭背景下的重要性，我们评估了白细胞介素（IL）-1基因簇的多态性，包括IL-1α、IL-1β、白细胞介素-1受体拮抗剂（IL-1RA）和IL-1R基因，是否是缺血性心脏病所致CHF的预测指标。
本研究招募了43例缺血性心力衰竭患者作为患者组，并与140名健康无关对照者进行比较。采用序列特异性引物聚合酶链反应方法，测定IL-1α（-889）、IL-1β（-511、+3962）、IL-1R（psti 1970）和IL-1RA（mspa1 11100）基因内5个单核苷酸多态性（SNP）的等位基因和基因型频率。
患者组中IL-1β -511/C等位基因频率显著高于对照组（p = 0.031）。与对照组相比，患者中IL-1β（-511）C/C基因型显著过多（p = 0.022）。
缺血性心力衰竭患者中IL-1β基因的特定等位基因和基因型过多，可能影响个体对该病的易感性（表1，参考文献27）。
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