内镜超声引导下乙醇消融治疗胰腺神经内分泌肿瘤的疗效与安全性

Efficacy and Safety of Endoscopic Ultrasound-guided Ethanol Ablation Therapy for Pancreatic Neuroendocrine Tumors.

作者信息

Matsumoto Kazuyuki, Kato Hironari, Tsutsumi Koichiro, Mizukawa Sho, Yabe Syuntaro, Seki Hiroyuki, Akimoto Yutaka, Uchida Daisuke, Tomoda Takeshi, Yamamoto Naoki, Horiguchi Shigeru, Okada Hiroyuki

机构信息

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

出版信息

Acta Med Okayama. 2016 Aug;70(4):313-6. doi: 10.18926/AMO/54511.

DOI:10.18926/AMO/54511

PMID:27549680

Abstract

Recently, endoscopic ultrasonography (EUS)-guided ethanol ablation for small pancreatic neuroendocrine tumors (p-NETs) has been reported. However, the efficacy and safety of the technique remain unclear. We have launched a prospective pilot study of EUS-guided ethanol ablation for p-NETs. The major eligibility criteria are the presence of a pathologically diagnosed grade (G) 1 or G2 p-NET, a tumor size of 2cm, and being a poor candidate for surgery. A total of 5 patients will be treated. The primary endpoint will be the complete ablation rate at 1 month after treatment.

摘要

最近，有报道称采用内镜超声（EUS）引导下乙醇消融术治疗小胰腺神经内分泌肿瘤（p-NETs）。然而，该技术的疗效和安全性仍不明确。我们已开展一项关于EUS引导下乙醇消融术治疗p-NETs的前瞻性试点研究。主要入选标准为病理诊断为1级（G1）或2级（G2）的p-NET、肿瘤大小为2cm且不适合手术治疗。共有5名患者将接受治疗。主要终点将是治疗后1个月的完全消融率。