血浆渗出。豚鼠气道体内伊文思蓝染料与放射性标记白蛋白之间的相关性。

Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo.

作者信息

Rogers D F, Boschetto P, Barnes P J

机构信息

Department of Thoracic Medicine, National Heart & Lung Institute, London, United Kingdom.

出版信息

J Pharmacol Methods. 1989 Jul;21(4):309-15. doi: 10.1016/0160-5402(89)90068-5.

DOI:10.1016/0160-5402(89)90068-5

PMID:2755146

Abstract

We quantified the tissue exudation and luminal transudation of two plasma markers, Evans blue (EB) dye and [125I]-human serum albumin (HSA), into the airways of the anesthetized guinea pig in response to platelet activating factor (PAF). There was a highly significant correlation between the tissue content of EB and [125I]-HSA in all airways studied. Significant correlation for transudation of the two markers was limited to high rates of plasma leakage. [125I]-HSA was the more sensitive marker for the association between exudation and transudation and the effect of PAF on transudation. EB was the better marker for assessing the relationship between the dose of PAF and plasma exudation.

摘要

我们对两种血浆标志物伊文思蓝（EB）染料和[125I] - 人血清白蛋白（HSA）在麻醉豚鼠气道中的组织渗出和管腔漏出情况进行了定量，以研究其对血小板活化因子（PAF）的反应。在所有研究的气道中，EB的组织含量与[125I] - HSA之间存在高度显著的相关性。两种标志物漏出的显著相关性仅限于血浆高渗漏率情况。[125I] - HSA是渗出与漏出之间关联以及PAF对漏出影响的更敏感标志物。EB是评估PAF剂量与血浆渗出之间关系的更好标志物。