癌症中的Wnt5a信号传导
Wnt5a Signaling in Cancer.
作者信息
Asem Marwa S, Buechler Steven, Wates Rebecca Burkhalter, Miller Daniel L, Stack M Sharon
机构信息
Integrated Biomedical Sciences Program, Department of Chemistry and Biochemistry, Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA.
Department of Applied and Computational Mathematics and Statistics, Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46656, USA.
出版信息
Cancers (Basel). 2016 Aug 26;8(9):79. doi: 10.3390/cancers8090079.
Wnt5a is involved in activating several non-canonical WNT signaling pathways, through binding to different members of the Frizzled- and Ror-family receptors. Wnt5a signaling is critical for regulating normal developmental processes, including proliferation, differentiation, migration, adhesion and polarity. However, the aberrant activation or inhibition of Wnt5a signaling is emerging as an important event in cancer progression, exerting both oncogenic and tumor suppressive effects. Recent studies show the involvement of Wnt5a in regulating cancer cell invasion, metastasis, metabolism and inflammation. In this article, we review findings regarding the molecular mechanisms and roles of Wnt5a signaling in various cancer types, and highlight Wnt5a in ovarian cancer.
Wnt5a通过与卷曲蛋白（Frizzled）家族和受体酪氨酸激酶样孤儿受体（Ror）家族的不同成员结合，参与激活多种非经典WNT信号通路。Wnt5a信号对于调节正常发育过程至关重要，包括增殖、分化、迁移、黏附和极性。然而，Wnt5a信号的异常激活或抑制正成为癌症进展中的一个重要事件，发挥着致癌和抑癌作用。最近的研究表明Wnt5a参与调节癌细胞的侵袭、转移、代谢和炎症。在本文中，我们综述了关于Wnt5a信号在各种癌症类型中的分子机制和作用的研究结果，并重点介绍了卵巢癌中的Wnt5a。
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