Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
J Clin Psychiatry. 2016 Oct;77(10):e1211-e1217. doi: 10.4088/JCP.15m09965.
Craving is associated with a high probability of relapse. However, the relationship between functional connectivity in the default mode network (DMN) during resting state and basal craving of heroin-dependent individuals remains unknown.
Data used in the present study were collected between August 10, 2009, and June 28, 2011. Twenty-four male heroin-dependent individuals based on DSM-IV criteria and 20 male healthy control subjects participated in a study of resting-state functional magnetic resonance imaging. The basal heroin craving of the heroin-dependent group was evaluated. The DMN networks were identified by group independent component analysis. The between-group difference in functional connectivity was analyzed, and the relationship between functional connectivity in the DMN and basal heroin craving in the heroin-dependent group was also analyzed.
In all subjects, 2 spatially independent default mode subnetworks were identified: the anterior and posterior subnetworks. The anterior subnetwork, mainly the dorsal medial prefrontal cortex, showed decreased functional connectivity in the heroin-dependent group relative to the healthy control group (P < .05, familywise error corrected). However, the functional connectivity in dorsal medial prefrontal cortex was negatively correlated with the basal craving of the heroin group (P = .01, r = -0.50). No significant difference in the functional connectivity of the posterior subnetwork was found.
Our findings suggest that abnormal functional connectivity within the anterior subnetwork of DMN in heroin-dependent individuals is associated with basal heroin craving, and it may serve as neural underpinnings for the mechanism of heroin addiction.
成瘾渴求与高复发率相关。然而，静息状态下默认模式网络（DMN）的功能连接与海洛因依赖个体的基础渴求之间的关系尚不清楚。
本研究的数据收集于 2009 年 8 月 10 日至 2011 年 6 月 28 日。24 名符合 DSM-IV 标准的男性海洛因依赖者和 20 名男性健康对照者参与了静息态功能磁共振成像研究。评估海洛因依赖组的基础海洛因渴求。通过组独立成分分析确定 DMN 网络。分析组间功能连接的差异，并分析 DMN 中的功能连接与海洛因依赖组的基础海洛因渴求之间的关系。
在所有受试者中，识别出 2 个空间独立的默认模式子网：前子网和后子网。前子网主要是背内侧前额皮质，与健康对照组相比，海洛因依赖组的功能连接降低（P <.05，经校正的家族性错误）。然而，背内侧前额皮质的功能连接与海洛因组的基础渴求呈负相关（P =.01，r = -0.50）。未发现后子网功能连接的显著差异。
我们的发现表明，海洛因依赖个体 DMN 前子网内的异常功能连接与基础海洛因渴求有关，它可能是海洛因成瘾机制的神经基础。
