肾间质纤维化中的内皮功能障碍
Endothelial Dysfunction in Renal Interstitial Fibrosis.
作者信息
Perry Heather M, Okusa Mark D
机构信息
Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, Va., USA.
出版信息
Nephron. 2016;134(3):167-171. doi: 10.1159/000447607. Epub 2016 Aug 30.
Abstract
Kidney disease affects millions of people worldwide and it is now widely accepted that many pathological processes may persist after acute kidney injury that can cause the progression to CKD. Tubulointerstitial fibrosis manifests soon after injury and while many cellular and molecular components of kidney fibrosis have been discovered, largely in animal models, new therapeutic strategies are still desperately needed. The renal endothelium has emerged as important in progression of fibrosis through regulation of hypoxia, inflammation and cellular crosstalk. This review aims to highlight our current understanding of the role of the endothelium in interstitial fibrosis and to identify potential therapeutic targets. © 2016 S. Karger AG, Basel.
摘要
肾脏疾病影响着全球数百万人，目前人们普遍认为，急性肾损伤后可能会持续存在许多病理过程，这些过程会导致疾病进展为慢性肾脏病。肾小管间质纤维化在损伤后很快就会出现，虽然已经发现了肾脏纤维化的许多细胞和分子成分，这主要是在动物模型中发现的，但仍然迫切需要新的治疗策略。肾内皮在纤维化进展过程中通过调节缺氧、炎症和细胞间相互作用而发挥重要作用。本综述旨在强调我们目前对内皮在间质纤维化中作用的理解，并确定潜在的治疗靶点。© 2016 S. Karger AG，巴塞尔。
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