Yossef Ofry Efraim, Farajian Mor, Gilad Ilan, Willenz Udi, Gutman Nimrod, Yosibash Zohar
Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
Lahav CRO, Kibbutz Lahav 85335, Israel.
J Mech Behav Biomed Mater. 2017 Jan;65:177-189. doi: 10.1016/j.jmbbm.2016.08.013. Epub 2016 Aug 11.
Further experimental evidence on the compressibility of arteries under normal physiological pressure range is provided using the experimental apparatus introduced in Yosibash et al., JMBBM 39(2014):339-354. We enlarged the experimental database by including almost twice the number of experiments, we considered a different artery - the porcine common carotid that allowed longer and larger diameters. In the physiological pressure range of 50-200mmHg, a relative volume change of 5% was obtained, lower compared to the sapheneous and femoral arteries (2-6%). Most of the arteries had a relative volume change of 1.5%. The relative volume change is found to be almost linearly proportional to the pressure, and inversely proportional to the dimensions of the experimented arteries (especially the artery length). The smaller the artery tested, the larger the relative volume change (such a phenomenon was also realized in Yosibash et al., JMBBM 39(2014):339-354.). We realized in recent past publications a flaw in the experimental protocol that results in an overestimation of the relative volume change (thus underestimating the bulk modulus). It is due to the consideration of experimental observations close to the zero pressure. Nontheless, in view of the experimental evidence, the pre-assumption of incompressibility in many phenomenological constitutive models of artery walls should be re-evaluated.
利用Yosibash等人在《生物力学与生物医学工程杂志》39卷(2014年):339 - 354页中介绍的实验装置,提供了关于正常生理压力范围内动脉可压缩性的进一步实验证据。我们通过纳入几乎两倍数量的实验扩大了实验数据库,我们考虑了一种不同的动脉——猪的颈总动脉,其直径更长且更大。在50 - 200mmHg的生理压力范围内,获得了5%的相对体积变化,与隐动脉和股动脉(2 - 6%)相比更低。大多数动脉的相对体积变化为1.5%。发现相对体积变化几乎与压力成正比,与实验动脉的尺寸(尤其是动脉长度)成反比。所测试的动脉越小,相对体积变化越大(Yosibash等人在《生物力学与生物医学工程杂志》39卷(2014年):339 - 354页中也认识到了这种现象)。我们在最近的出版物中意识到实验方案存在一个缺陷,该缺陷导致相对体积变化被高估(从而低估了体积模量)。这是由于考虑了接近零压力的实验观测值。尽管如此,鉴于实验证据,许多动脉壁唯象本构模型中不可压缩性的预先假设应该重新评估。