In order to improve the electro-catalytic activity and catalytic reaction rate of graphite-like material, Tin dioxide-Titanium dioxide/Nano-graphite (SnO-TiO/Nano-G) composite was synthesized by a sol-gel method and SnO-TiO/Nano-G electrode was prepared in hot-press approach. The composite was characterized by X-ray photoelectron spectroscopy, fourier transform infrared, Raman, N adsorption-desorption, scanning electrons microscopy, transmission electron microscopy and X-ray diffraction. The electrochemical performance of the SnO-TiO/Nano-G anode electrode was investigated via cyclic voltammetry and electrochemical impedance spectroscopy. The electro-catalytic performance was evaluated by the degradation of ceftriaxone sodium and the yield of ·OH radicals in the reaction system. The results demonstrated that TiO, SnO and Nano-G were composited successfully, and TiO and SnO particles dispersed on the surface and interlamination of the Nano-G uniformly. The specific surface area of SnO modified anode was higher than that of TiO/Nano-G anode and the degradation rate of ceftriaxone sodium within 120 min on SnO-TiO/Nano-G electrode was 98.7% at applied bias of 2.0 V. The highly efficient electro-chemical property of SnO-TiO/Nano-G electrode was attributed to the admirable conductive property of the Nano-G and SnO-TiO/Nano-G electrode. Moreover, the contribution of reactive species ·OH was detected, indicating the considerable electro-catalytic activity of SnO-TiO/Nano-G electrode.