全血中3,4-亚甲二氧基苯丙胺和3,4-亚甲二氧基甲基苯丙胺对映体的测定。
Determination of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine enantiomers in whole blood.
作者信息
Fitzgerald R L, Blanke R V, Glennon R A, Yousif M Y, Rosecrans J A, Poklis A
机构信息
Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond 23298.
出版信息
J Chromatogr. 1989 May 5;490(1):59-69. doi: 10.1016/s0378-4347(00)82761-9.
A method for the determination of the enantiomeric content of 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) in microsamples (200 microliters) of whole blood is described. The method involves liquid-liquid extraction of MDA and MDMA from blood and derivatization with the chiral reagent N-trifluoroacetyl-L-prolyl chloride. Separation, identification and quantitation of diastereomeric derivatives is by gas chromatography-mass spectrometry. The analytical range of the assay is from 0.12 ng to 48 ng injected on-column. Details for the synthesis of the enantiomers of MDMA are also provided.
描述了一种测定全血微量样本（200微升）中3,4-亚甲基二氧基苯丙胺（MDA）和3,4-亚甲基二氧基甲基苯丙胺（摇头丸）对映体含量的方法。该方法包括从血液中液-液萃取MDA和摇头丸，并用手性试剂N-三氟乙酰基-L-脯氨酰氯进行衍生化。非对映体衍生物的分离、鉴定和定量通过气相色谱-质谱法进行。该测定的分析范围是柱上进样0.12纳克至48纳克。还提供了摇头丸对映体合成的详细信息。
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