Nuño Laura, Joven Beatriz, Carreira Patricia, Maldonado Valentina, Larena Carmen, Llorente Irene, Tomero Eva, Barbadillo María Carmen, García-de la Peña Paloma, Ruiz Lucía, López-Robledillo Juan Carlos, Moruno Henry, Pérez Ana, Cobo-Ibáñez Tatiana, Almodóvar Raquel, Lojo Leticia, Monteagudo Indalecio, García-De Yébenes María Jesús, López-Longo Francisco Javier
Servicio de Reumatología, Hospital La Paz, Madrid, España.
Servicio de Reumatología, Hospital Doce de Octubre, Madrid, España.
Reumatol Clin. 2017 Nov-Dec;13(6):331-337. doi: 10.1016/j.reuma.2016.07.010. Epub 2016 Sep 5.
To analyze clinical characteristics, survival and causes of death of patients diagnosed with autoimmune inflammatory myositis in the REMICAM registry from the Society of Rheumatology in the Community of Madrid (SORCOM).
Multicenter cohort of patients diagnosed with autoimmune inflammatory myopathy with follow-up between January 1980 and December 2014. A total of 313 variables concerning demographic, clinical and morbidity data were collected, and a comparison was performed between clinical subgroups.
A total of 479 patients were recruited from 12 centers, with 14% of patients lost to follow-up. Seventy-four percent of cases were women, age at diagnosis of 44±23 years and a mean follow-up period of 10±8 years. The most frequent clinical subgroups were primary myositis (PM 29%, DM 22%), followed by overlap myositis (20.5%), juvenile myositis (18%), myositis associated with cancer (8%), immune-mediated necrotizing myositis (1%) and inclusion body myositis (1%). During the follow-up period, a total of 114 deaths (28%) were registered, the main causes being cancer (24%), infections (23%) and cardiovascular events (21%).
A total of 479 patients were recruited in the REMICAM registry of inflammatory myopathies. Including sociodemographic, clinical and prognostic information, it represents the largest Spanish multicenter registry to date in rheumatology, and constitutes an important source for conducting further substudies.
分析马德里自治区风湿病学会（SORCOM）的REMICAM注册研究中诊断为自身免疫性炎性肌病患者的临床特征、生存率和死亡原因。
对1980年1月至2014年12月期间诊断为自身免疫性炎性肌病且进行随访的患者进行多中心队列研究。收集了总共313项有关人口统计学、临床和发病数据的变量，并对临床亚组进行了比较。
从12个中心招募了479例患者，14%的患者失访。74%的病例为女性，诊断时年龄为44±23岁，平均随访期为10±8年。最常见的临床亚组是原发性肌炎（PM 29%，DM 22%），其次是重叠性肌炎（20.5%）、青少年肌炎（18%）、与癌症相关的肌炎（8%）、免疫介导的坏死性肌炎（1%）和包涵体肌炎（1%）。在随访期间，共记录了114例死亡（28%），主要原因是癌症（24%）、感染（23%）和心血管事件（21%）。
REMICAM炎性肌病注册研究共招募了479例患者。该研究包括社会人口统计学、临床和预后信息，是迄今为止西班牙风湿病领域最大的多中心注册研究，也是进行进一步亚研究的重要来源。
