Méndez Romero Alejandra, de Man Robert A
Department of Radiation Oncology, Erasmus MC University Medical Center (Cancer Institute), Rotterdam, The Netherlands.
Department of Gastroenterology & Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Best Pract Res Clin Gastroenterol. 2016 Aug;30(4):603-16. doi: 10.1016/j.bpg.2016.06.003. Epub 2016 Jun 25.
Technical developments allowed stereotactic body radiation therapy (SBRT) to deliver effective doses of irradiation with high precision in a small number of fractions. This paper reviews the role of SBRT for liver metastases, hepatocellular carcinoma and cholangiocarcinoma, paying special attention to patient eligibility and treatment outcomes regarding local control, toxicity and quality of life. As well as discussing specific issues of these different tumors, such as the presence of underlying liver cirrhosis and the impact on toxicity, it outlines the limitations of SBRT and future areas of development and research.
技术的发展使得立体定向体部放射治疗（SBRT）能够以少量分次照射的方式高精度地给予有效剂量的辐射。本文回顾了SBRT在肝转移瘤、肝细胞癌和胆管癌治疗中的作用，特别关注患者的入选标准以及局部控制、毒性和生活质量方面的治疗结果。除了讨论这些不同肿瘤的具体问题，如潜在肝硬化的存在及其对毒性的影响外，还概述了SBRT的局限性以及未来的发展和研究领域。
