Peng Y, Fu Y X
The First Clinical College of Chongqing Medical University, Chongqing 400016, China.
Zhonghua Shao Shang Za Zhi. 2016 Sep 20;32(9):539-41. doi: 10.3760/cma.j.issn.1009-2587.2016.09.006.
It is imperative to research the treatment strategy for infections caused by multi-drug resistant (MDR) bacteria, as there are increasing reports showing that more and more patients are decimated by the infections of MDR bacteria and the development of antimicrobial drugs is in downturn. Current researches mainly focus on the following three aspects: developing new antimicrobial agents with the aid of basic scientific achievements in finding new antibacterial targets, achieving antimicrobial purpose by specific lysis of host bacteria with phages of high specificity, and killing bacteria potently by destroying its cytomembrane using broad-spectrum antimicrobial peptides.
研究耐多药(MDR)细菌引起的感染的治疗策略势在必行,因为越来越多的报告表明,越来越多的患者因耐多药细菌感染而死亡,且抗菌药物的研发正处于低迷状态。目前的研究主要集中在以下三个方面:借助寻找新抗菌靶点的基础科学成果开发新型抗菌剂;利用高特异性噬菌体特异性裂解宿主细菌来实现抗菌目的;使用广谱抗菌肽破坏细菌细胞膜从而有效杀死细菌。