人类多能干细胞中的持续染色体不稳定——DNA复制的作用
Continuous chromosomal instability in human pluripotent stem cells - the role of DNA replication.
作者信息
Lamm Noa, Kerem Batsheva
机构信息
Department of Genetics, The Hebrew University , Jerusalem, Israel.
出版信息
Mol Cell Oncol. 2016 May 12;3(4):e1183743. doi: 10.1080/23723556.2016.1183743. eCollection 2016 Jul.
Abstract
Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.
摘要
人类多能干细胞（hPSCs）在培养过程中经常出现染色体畸变，包括非整倍体。最近，我们发现了一种基于复制应激的机制，该机制导致非整倍体hPSCs中持续的染色体不稳定，这种机制可能在二倍体细胞不稳定的起始阶段也起作用。
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