一种基于结构的转录动力学模型。
A structure-based kinetic model of transcription.
作者信息
Zuo Yuhong, Steitz Thomas A
机构信息
a Department of Molecular Biophysics and Biochemistry , Yale University , New Haven , CT , USA.
b Howard Hughes Medical Institute , New Haven , CT , USA.
出版信息
Transcription. 2017 Jan;8(1):1-8. doi: 10.1080/21541264.2016.1234821. Epub 2016 Sep 22.
Abstract
During transcription, RNA polymerase moves downstream along the DNA template and maintains a transcription bubble. Several recent structural studies of transcription complexes with a complete transcription bubble provide new insights into how RNAP couples the nucleotide addition reaction to its directional movement.
摘要
在转录过程中，RNA聚合酶沿着DNA模板向下游移动，并维持一个转录泡。最近对具有完整转录泡的转录复合物进行的几项结构研究，为RNA聚合酶如何将核苷酸添加反应与其定向移动耦合提供了新的见解。
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