幼马感染非灵长类肝炎病毒的急性和慢性感染
Acute and chronic infections with nonprimate hepacivirus in young horses.
作者信息
Gather Theresa, Walter Stephanie, Pfaender Stephanie, Todt Daniel, Feige Karsten, Steinmann Eike, Cavalleri Jessika M V
机构信息
Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Bünteweg 9, 30559, Hannover, Germany.
Institute for Experimental Virology, TWINCORE Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
出版信息
Vet Res. 2016 Sep 22;47(1):97. doi: 10.1186/s13567-016-0381-6.
The recently discovered nonprimate hepacivirus (NPHV) naturally infects horses and is the closest known homolog of hepatitis C virus to date. Within a follow-up study acute field infections were monitored in four young Thoroughbred horses until the ages of 12-13 months. Serum samples were analyzed for the presence of NPHV RNA and anti-NPHV NS3 antibodies and liver specific parameters were evaluated. The four young horses were not able to clear infection, but remained chronically infected for the entire monitored time period despite the presence of NPHV specific antibodies.
最近发现的非灵长类丙型肝炎病毒（NPHV）可自然感染马匹，是迄今为止已知的与丙型肝炎病毒最接近的同源病毒。在一项随访研究中，对4匹年轻的纯种马进行了急性野外感染监测，直至它们12至13个月大。分析血清样本中是否存在NPHV RNA和抗NPHV NS3抗体，并评估肝脏特异性参数。这4匹年轻的马无法清除感染，尽管存在NPHV特异性抗体，但在整个监测时间段内仍处于慢性感染状态。
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