Comparison of serum levels of IL-18 in peripheral blood of patients with type II diabetes with nephropathy clinical protests and patients with type II diabetes without nephropathy clinical protests.

BACKGROUND AND AIM

Interleukin (IL)-18 is a proinflammatory cytokine secreted from mononuclear cells. Serum concentration of IL-18 is a strong predictor of death in patients with cardiovascular diseases. Recent studies have shown that microinflammation is involved in the pathogenesis of diabetic nephropathy as well as of cardiovascular diseases. This study aimed to test the hypothesis that the serum level of IL-18 is a common predictor of nephropathy and atherosclerosis in patients with type 2 diabetes.

MATERIALS AND METHODS

69 diabetic patient that have documented file in two centers (Ali asghar hospital and dialysis center of Imam ali hospital) had selected. 32 patients with type 2 nephropathic diabetes and 37 age- and sex-matched control subjects with type 2 diabetes that haven't any sign and symptom of nephropathy were enrolled.then take 5 ml blood from peripheral veins. Patients with positive CRP were excluded(2 patients in control group and 1 patient in case group). We assessed measured serum IL-18 levels in all patients.

FINDINGS

Serum IL-18 levels were significantly elevated in patients with type 2 diabetes with nephropathy as compared with control subjects (serum IL-18 261.29±20.25 vs. 167.20±13.48 pg/ml, P<0.001. the all patients in case control have upper level of serum IL-18 vs the control group.

DISCUSSION AND CONCLUSIONS

Serum levels of IL-18 in nephropathic patient significantly rise and Serum levels of IL-18 might be a predictor factor of progression of diabetic nephropathy.