Caca-Biljanovska Nina, Arsovska-Bezhoska Irina, V'lckova-Laskoska Marija
Irina Arsovska-Bezhoska, MD, Department of Dermatology, University of Ss. Cyril and Methodius, Naroden Front 35/13, Skopje, R. of Macedonia;
Acta Dermatovenerol Croat. 2016 Aug;24(3):214-7.
The association between psoriasis vulgaris and bullous pemphigoid is due to the still unclear autoimmune process. The common disease site is the dermo-epidermal junction or basal membrane zone (BMZ), with specific alterations for both diseases. Photochemotherapy (PUVA) is one of the therapeutic modalities for psoriasis and can trigger production of autoantibodies against antigens in the BMZ in patients with subclinical bullous pemphigoid. Furthermore, PUVA therapy can alter the immunological milieu and hence can contribute to the expression of bullous pemphigoid in patients with psoriasis. We observed a bullous eruption compatible with bullous pemphigoid in a psoriatic patient treated with PUVA. We speculate that the cumulative dose of PUVA sufficient for triggering blister formation is individually determined.
寻常型银屑病与大疱性类天疱疮之间的关联归因于仍不清楚的自身免疫过程。常见的疾病部位是真皮-表皮交界处或基底膜带（BMZ），两种疾病都有特定的改变。光化学疗法（PUVA）是银屑病的治疗方式之一，可在亚临床大疱性类天疱疮患者中引发针对BMZ中抗原的自身抗体产生。此外，PUVA疗法可改变免疫环境，因此可促使银屑病患者发生大疱性类天疱疮。我们在一名接受PUVA治疗的银屑病患者中观察到了与大疱性类天疱疮相符的水疱性皮疹。我们推测，足以引发水疱形成的PUVA累积剂量是因人而异的。
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