[Effect of yin zhi huang on bilirubin excretion in animals with unconjugated hyperbilirubinemia].

Yin Zhi Huang (YZH) given stomach perfusion daily for three days in rabbits accelerated plasma clearance of infused unconjugated bilirubin. A similar but less dramatic effect could be obtained by using YZH or phenobarbital i. p. daily for three days in rats employing simultaneously with the method of bile duct ligation, plasma indirect bilirubin levels was lower but hepatic bilirubin content and plasma direct bilirubin levels were higher in both YZH and phenobarbital treated rats than those in the control animals. These observations suggested that YZH and phenobarbital shared a common mechanism of acting in lowering the indirect bilirubin levels of serum.