Linkage studies of Myotonia congenita and Paramyotonia congenita.
作者信息
Bender K, Senff H, Steiert A, Lagodny H, Wienker T F, Koch M
机构信息
Institut für Humangenetik und Anthropologie, Universität Freiburg, FRG.
出版信息
Clin Genet. 1989 Aug;36(2):92-9. doi: 10.1111/j.1399-0004.1989.tb03170.x.
Abstract
Six German families segregating for Myotonia congenita (MC) and eight families from Germany and Great Britain with Paramyotonia congenita (PC) were tested for linkage relationships using 35 serological and biochemical markers. No linkage of MC to any of the markers was evident, but a positive sum of lod scores for PC vs. the HP locus (z = 1.16, theta = 0.16) was found. The results encourage further investigations involving chromosome 16 markers.
摘要
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