C19 Δ5-类固醇在肾上腺皮质功能不全胰岛素耐量试验中对促肾上腺皮质激素刺激和低血糖的反应。

The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency.

作者信息

Dušková Michaela, Kolátorová Sosvorová Lucie, Hill Martin, Šimůnková Kateřina, Jandíková Hana, Pospíšilová Hana, Šrámková Monika, Kosák Mikuláš, Kršek Michal, Hána Václav, Stárka Luboslav

机构信息

Institute of Endocrinology, Prague, Czech Republic.

3rd Department of Medicine - Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

出版信息

Prague Med Rep. 2016;117(2-3):98-107. doi: 10.14712/23362936.2016.10.

DOI:10.14712/23362936.2016.10

PMID:27668526

Abstract

Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHEAS) are valuable markers of the integrity of the HPA (hypothalamus-pituitary-adrenal) axis. Assessments of HPA function should rely on measurements of baseline and/or stimulated serum cortisol concentrations, and C19 Δ5-steroids may provide additional information. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds.

摘要

关于促肾上腺皮质激素（ACTH）或胰岛素诱导的低血糖刺激肾上腺雄激素分泌的时间进程研究，通常仅限于脱氢表雄酮和/或其硫酸盐。我们关于脱氢表雄酮（DHEA）及其羟基化代谢物的数据清楚地表明，DHEA及其硫酸盐（DHEAS）的测量是下丘脑-垂体-肾上腺（HPA）轴完整性的重要标志物。HPA功能评估应依赖于基线和/或刺激后血清皮质醇浓度的测量，C19 Δ5-类固醇可能提供额外信息。对DHEA的7-和16-羟基化代谢物的刺激研究有助于我们理解这些化合物的形成顺序。