Malinowski Bartosz, Fulgheri Gabriele, Wicinski Michal, Grzesk Elzbieta, Odrowaz-Sypniewska Grazyna, Grześk Grzegorz, Darwish Nasser
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University , Bydgoszcz, Poland.
EJIFCC. 2012 Jul 18;23(2):41-6. eCollection 2012 Jul.
Cardiomyopathies are diagnosed based on medical history of patient (symptoms and family history), physical examination, results of echocardiogram and in some situations additionally ECG or chest-X-ray results. Currently used non-invasive diagnostic methods, could be complemented by biochemical tests. In this review some emerging potential biomarkers such as: osteopontin, ST-2 receptor, osteoprotegerin, neopterin, urocortins, growth differentiation factor 15 and urotensin II are described. In current article human and non human investigations have been reviewed, since rat is most commonly used model in experimental cardiology and gives important foundations to clinical knowledge.
心肌病的诊断基于患者的病史(症状和家族史)、体格检查、超声心动图结果,在某些情况下还需结合心电图或胸部X光检查结果。目前使用的非侵入性诊断方法可辅以生化检测。在本综述中,描述了一些新兴的潜在生物标志物,如骨桥蛋白、ST-2受体、骨保护素、新蝶呤、促肾上腺皮质激素释放激素、生长分化因子15和尾加压素II。在本文中,对人类和非人类的研究进行了综述,因为大鼠是实验心脏病学中最常用的模型,为临床知识提供了重要基础。