Virtanen Kirsi A
Turku PET Centre, Turku University Hospital and University of Turku, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Best Pract Res Clin Endocrinol Metab. 2016 Aug;30(4):471-477. doi: 10.1016/j.beem.2016.09.001. Epub 2016 Sep 10.
Human brown adipose tissue has been acknowledged in newborns and children but in adults the first printed publications are from the beginning of 20th century. Further evidence of the existence of adult brown fat was published throughout the century but only very recently the functionality of active brown adipose tissue in vivo in adulthood was confirmed. This was contributed mainly by advanced imaging technology, namely hybrid positron emission tomography (PET) and computed tomography (CT), being able to combine functional and anatomical imaging data. Functionality is most commonly measured with glucose analog, 18F-fluoro-2-deoxy-d-glucose (FDG) but other tracers for other functions than glucose uptake have been introduced as well. Growing body of evidence has increased the knowledge of the role of brown adipose tissue in human metabolism and energy expenditure, providing a promising option for the management of body weight balance and disturbed glucose and lipid metabolism.
人类棕色脂肪组织在新生儿和儿童中已得到确认，但在成人中，最早的印刷出版物始于20世纪初。整个世纪都有关于成人棕色脂肪存在的进一步证据发表，但直到最近，成年人体内活跃棕色脂肪组织的功能才得到证实。这主要得益于先进的成像技术，即正电子发射断层扫描（PET）和计算机断层扫描（CT）相结合，能够整合功能和解剖成像数据。功能最常用葡萄糖类似物18F-氟-2-脱氧-D-葡萄糖（FDG）来测量，但也引入了用于其他功能而非葡萄糖摄取的其他示踪剂。越来越多的证据增加了我们对棕色脂肪组织在人类新陈代谢和能量消耗中作用的认识，为体重平衡以及葡萄糖和脂质代谢紊乱的管理提供了一个有前景的选择。
