Ai Qi, Yin Jing, Chen Sen, Qiao Lijin, Luo Na
Department of Hematology, Tianjin Children's Hospital, Tianjin 301800, P.R. China.
Department of Rheumatology, Tianjin Children's Hospital, Tianjin 301800, P.R. China; Department of Immunology, School of Medicine, Nankai University, Tianjin 300071, P.R. China.
Exp Ther Med. 2016 Oct;12(4):2187-2190. doi: 10.3892/etm.2016.3582. Epub 2016 Aug 9.
Certain studies have previously indicated that an association may exist between rotavirus infection and primary immune thrombocytopenic purpura (ITP). The present retrospective study aimed to investigate whether rotavirus may cause ITP in children. Firstly, the incidence of ITP in children with or without rotavirus diarrhea was compared. A 14.58% incident rate was observed in children with rotavirus diarrhea compared with a 7.22% incident rate in children without rotavirus diarrhea. Subsequently, the clinical features of ITP children with or without rotavirus infection were compared. The results indicated that ITP children with rotavirus infection were significantly younger, showed significantly decreased mean platelet volume (MPV) levels and presented a significantly higher frequency of bleeding score of 3 against ITP children without rotavirus infection. In conclusion, these findings suggest that rotavirus serves a causative role in ITP.
此前某些研究表明，轮状病毒感染与原发性免疫性血小板减少症（ITP）之间可能存在关联。本回顾性研究旨在调查轮状病毒是否会导致儿童ITP。首先，比较了患或未患轮状病毒性腹泻儿童的ITP发病率。观察到患轮状病毒性腹泻儿童的发病率为14.58%，而未患轮状病毒性腹泻儿童的发病率为7.22%。随后，比较了感染或未感染轮状病毒的ITP儿童的临床特征。结果表明，与未感染轮状病毒的ITP儿童相比，感染轮状病毒的ITP儿童明显更年幼，平均血小板体积（MPV）水平显著降低，出血评分为3分的频率显著更高。总之，这些发现表明轮状病毒在ITP中起致病作用。
