相似文献
1
Deguelin inhibits proliferation and migration of human pancreatic cancer cells targeting hedgehog pathway.
Oncol Lett. 2016 Oct;12(4):2761-2765. doi: 10.3892/ol.2016.4928. Epub 2016 Aug 2.
2
Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway.
Oncotarget. 2017 Oct 26;9(1):152-166. doi: 10.18632/oncotarget.22077. eCollection 2018 Jan 2.
3
Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway.
Oncol Rep. 2016 Mar;35(3):1718-26. doi: 10.3892/or.2015.4504. Epub 2015 Dec 22.
4
Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.
Cell Signal. 2018 Oct;50:131-141. doi: 10.1016/j.cellsig.2018.07.001. Epub 2018 Jul 7.
5
Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways.
Am J Chin Med. 2018;46(1):209-229. doi: 10.1142/S0192415X1850012X.
6
Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.
Cancer Prev Res (Phila). 2009 Nov;2(11):942-50. doi: 10.1158/1940-6207.CAPR-08-0232. Epub 2009 Oct 27.
7
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
J Immunol. 2006 Oct 15;177(8):5612-22. doi: 10.4049/jimmunol.177.8.5612.
8
[Inhibitory effect of Akt inhibitor deguelin on the growth of PC-3 prostate cancer cells].
Zhonghua Nan Ke Xue. 2013 Jun;19(6):501-5.
9
Sea cucumber extract TBL-12 inhibits the proliferation, migration, and invasion of human prostate cancer cells through the p38 mitogen-activated protein kinase and intrinsic caspase apoptosis pathway.
Prostate. 2019 Jun;79(8):826-839. doi: 10.1002/pros.23788. Epub 2019 Mar 19.
10
Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-κB pathway.
Oncol Rep. 2016 Oct;36(4):2245-51. doi: 10.3892/or.2016.5044. Epub 2016 Aug 25.
引用本文的文献
1
Deguelin's Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry.
Front Pharmacol. 2025 Jun 26;16:1571452. doi: 10.3389/fphar.2025.1571452. eCollection 2025.
2
Harnessing Plant Flavonoids to Fight Pancreatic Cancer.
Curr Nutr Rep. 2024 Sep;13(3):566-581. doi: 10.1007/s13668-024-00545-9. Epub 2024 May 3.
3
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.
Signal Transduct Target Ther. 2023 Aug 18;8(1):315. doi: 10.1038/s41392-023-01559-5.
4
Potential Focal Adhesion Kinase Inhibitors in Management of Cancer: Therapeutic Opportunities from Herbal Medicine.
Int J Mol Sci. 2022 Nov 1;23(21):13334. doi: 10.3390/ijms232113334.
5
An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H--Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target.
Biomedicines. 2020 Oct 12;8(10):407. doi: 10.3390/biomedicines8100407.
6
Dauricine suppresses the growth of pancreatic cancer by modulating the Hedgehog signaling pathway.
Oncol Lett. 2019 Nov;18(5):4403-4414. doi: 10.3892/ol.2019.10790. Epub 2019 Sep 3.
7
Anticancer Effects of Constituents of Herbs Targeting Osteosarcoma.
Chin J Integr Med. 2019 Dec;25(12):948-955. doi: 10.1007/s11655-019-2941-x. Epub 2019 Jun 4.
8
The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts.
Viruses. 2018 Nov 7;10(11):614. doi: 10.3390/v10110614.
9
Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds.
Mol Nutr Food Res. 2018 Jan;62(1). doi: 10.1002/mnfr.201700621. Epub 2017 Dec 18.
10
Deguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2.
Thorac Cancer. 2017 Jul;8(4):320-327. doi: 10.1111/1759-7714.12444. Epub 2017 May 16.
本文引用的文献
1
Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression.
Med Oncol. 2014 Jul;31(7):41. doi: 10.1007/s12032-014-0041-5. Epub 2014 Jun 12.
2
The sonic hedgehog signaling pathway induces myopic development by activating matrix metalloproteinase (MMP)-2 in Guinea pigs.
PLoS One. 2014 May 8;9(5):e96952. doi: 10.1371/journal.pone.0096952. eCollection 2014.
3
Down-regulation of Gli-1 inhibits hepatocellular carcinoma cell migration and invasion.
Mol Cell Biochem. 2014 Aug;393(1-2):283-91. doi: 10.1007/s11010-014-2071-x. Epub 2014 May 3.
4
Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention.
Mol Clin Oncol. 2013 Mar;1(2):215-219. doi: 10.3892/mco.2012.36. Epub 2012 Oct 18.
5
Loss of HNF6 expression correlates with human pancreatic cancer progression.
Lab Invest. 2014 May;94(5):517-27. doi: 10.1038/labinvest.2014.47. Epub 2014 Mar 17.
6
Hedgehog signaling pathway is a potential therapeutic target for gallbladder cancer.
Cancer Sci. 2014 Mar;105(3):272-80. doi: 10.1111/cas.12354. Epub 2014 Feb 18.
7
Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS One. 2013 Jun 10;8(6):e65113. doi: 10.1371/journal.pone.0065113. Print 2013.
8
Matrix metalloproteinases in cancer: their value as diagnostic and prognostic markers and therapeutic targets.
Tumour Biol. 2013 Aug;34(4):2041-51. doi: 10.1007/s13277-013-0842-8. Epub 2013 May 17.
9
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.
Clin Exp Metastasis. 2013 Oct;30(7):855-66. doi: 10.1007/s10585-013-9585-6. Epub 2013 May 5.
10
Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.
Mol Cell Biochem. 2013 Jan;373(1-2):217-27. doi: 10.1007/s11010-012-1493-6. Epub 2012 Nov 6.
Zotero 插件